2011年8月24日 · ATG is an animal-derived product containing polyclonal antibodies, which are generated in either horse (Atgam, Lymphoglobulin, and Thymogam) or rabbit (Thymoglobulin) by inoculation with human thymocytes. Equine ATG has been used for the treatment of severe aplastic anemia since the 1980s.

2023年9月20日 · Atgam® (Anti-thymocyte Globulin [Equine]) is used for some blood disorders, including aplastic anemia and Myelodysplastic Syndrome (MDS). It is also used to prevent the body from rejecting a kidney transplant, and in some cases, to prevent or treat Graft Versus Host Disease (GvHD).

Adjunctive ATG (equine) therapy successfully reverses most initial episodes of acute rejection in renal allograft recipients, including a high percentage of episodes severe enough to require …

Anti-thymocyte globulin (ATG) is an infusion of horse or rabbit-derived antibodies against human T cells and their precursors (thymocytes), which is used in the prevention and treatment of acute rejection in organ transplantation and therapy of aplastic anemia due to …

Atgam, ATG equine (antithymocyte globulin equine) dosing, indications, interactions, adverse effects, and more. Range: 10-30 mg/kg IV qDay. Delaying onset of rejection (start within 24...

2017年12月7日 · Introduction: It is generally known that horse antithymocytic globulin (ATGAM) are more effective for treatment of pts with acquired AA than rabbit ATG. There is no doubt, that dose regime 160 mg/kg ATGAM Improves response for young pts after 1 st course.

ATGAM sterile solution contains lymphocyte immune globulin, anti-thymocyte globulin (equine). It is the purified, concentrated, and sterile gamma globulin, primarily monomeric IgG, from hyperimmune serum of horses immunized with human thymus lymphocytes. ATGAM is a transparent to slightly opalescent aqueous protein solution.

Renal allograft rejection Aplastic anemia (moderate to severe) in patients unsuitable for bone marrow transplantation. Limitations of Use: The usefulness of ATGAM has not been demonstrated in...

2011年8月4日 · Immunosuppressive therapy with antithymocyte globulin (ATG) plus cyclosporine is an effective alternative to stem-cell transplantation and improves blood counts and survival. Although horse...

We aimed to systematically review evidence to compare the efficacy and safety profiles of different ATGs. We did a systematic review and meta-analysis of randomized controlled trials (RCTs) and cohort controlled studies comparing horse and rabbit ATG in immunosuppressive therapy of treatment-naïve aplastic anemia.