2018年11月2日 · This study not only establishes the importance of Sel1L‐Hrd1 ERAD in the liver in the regulation of systemic energy metabolism, but also reveals a novel hepatic “ERAD‐Crebh‐Fgf21” axis directly linking ER protein turnover to gene transcription and systemic metabolic regulation.

2022年1月21日 · We show that ERAD gene expression is exponentially increased during chondrogenesis, and disruption of ERAD function causes severe chondrodysplasia in developing embryos and loss of adult articular cartilage. ERAD complex malfunction also causes abnormal accumulation of cartilage ECM molecules and subsequent chondrodysplasia.

2023年5月4日 · Here we report that the SEL1L–HRD1 protein complex—the most conserved branch of ER-associated degradation (ERAD)—is a negative regulator of the STING innate immunity by ubiquitinating...

Endoplasmic reticulum (ER)-associated degradation (ERAD) and the unfolded protein response (UPR) are two key quality-control machineries in the cell. ERAD is responsible for the clearance of misfolded proteins in the ER for cytosolic proteasomal degradation, while UPR is activated in response to the …

2023年5月30日 · Endoplasmic reticulum (ER)-associated degradation (ERAD) and ER-phagy are two principal degradative mechanisms for ER proteins and aggregates, respectively;...

2020年9月21日 · Here we report endoplasmic reticulum-associated degradation (ERAD) as a protein quality checkpoint that controls the haematopoietic stem cell (HSC)–niche interaction and determines the fate of...

2021年9月29日 · The endoplasmic reticulum quality control (ERQC) system, including endoplasmic reticulum-associated degradation (ERAD), the unfolded protein response (UPR), and autophagy, presides over cellular protein secretion and maintains proteostasis in mammalian cells. As part of the immune system, a variety …

ER Associated Degradation（ ERAD） qpcr array 2015-06-04 10:45 · 上海启因生物科技有限公司 运用高通量荧光定量PCR芯片方法，在一张96孔或384孔板上同时对某个信号通路或疾病相关基因的多个基因的表达量变化进行检测，芯片上的基因包括了与研究对象有确定关系的基因 ...

In this study, we report the role of hepatocyte-specific SEL1L-HRD1 ERAD in systemic iron homeostasis by regulating the maturation and turnover of CP in the ER. Mice with hepatocyte-specific Sel1L deficiency have altered basal iron homeostasis and altered response to iron deficiency and overload.

Protein quality-control machineries of the ER consist of three axes: acceleration of adequate protein folding, activation of the unfolded protein response (UPR), and protein clearance via ER-associated degradation (ERAD), or autophagy.