2024年12月25日 · ERCC3 (ERCC Excision Repair 3, TFIIH Core Complex Helicase Subunit) is a Protein Coding gene. Diseases associated with ERCC3 include Trichothiodystrophy 2, Photosensitive and Xeroderma Pigmentosum, Complementation Group B.

The ERCC3 gene variant that causes xeroderma pigmentosum changes one amino acid in the XPB protein. Specifically, the variant replaces the amino acid phenylalanine with the amino acid serine at protein position 99 (written as Phe99Ser or F99S).

2024年12月10日 · HIV-1 Rev interacting protein, excision repair cross-complementing rodent repair deficiency, complementation group 3 (ERCC3), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells

Reduced protein expression levels of DNA excision repair protein ERCC-3 (ERCC3) and XPA nucleotide excision repair protein (XPA) were associated with an increased risk of squamous cell carcinoma of head and neck (SCCHN).

该基因编码一种 ATP 依赖性 DNA 解旋酶，该解旋酶在核苷酸切除修复中发挥作用。 编码的蛋白质是基础转录因子 2 (TFIIH) 的一个亚基，因此也在 II 类转录中发挥作用。 该基因的突变与着色性干皮病 B、Cockayne 综合征和毛硫营养不良有关。 可变剪接导致多个转录本变体。 [RefSeq 提供，2014 年 12 月] This gene encodes an ATP-dependent DNA …

目的：探讨核苷酸切除修复交叉互补基因 3 （ Excision repair cross-complementation group 3，ERCC3）在肝细胞癌（Hepatocellular carcinoma，HCC） （以下简称肝癌）组织中的蛋白表达对肝癌患者术后预后的影响。

A recurrent heterozygous ERCC3 truncating mutation increases the risk for breast cancer in patients with Ashkenazi Jewish ancestry. Our study aimed to investigate the role of ERCC3 truncating variants in a cohort of patients with suspicion of HBOC.

核苷酸修复交叉互补基因3(Excision repair cross-complementation group 3,ERCC3)又称XPB,RAD25和TFIIH.ERCC3属于核苷酸剪切修复家族中的一员,它通过核苷酸的剪切修复(nucleotide excision repair,NER)的方式保护脱氧核糖核苷酸.着色素性干皮病和考卡因综合征的相关研究中发现,ERCC3发挥着 ...

2024年8月27日 · Associations between expression levels of nine core nucleotide excision repair genes in lymphocytes and risk of head and neck squamous cell carcinomas in a Chinese population. Spironolactone-induced degradation of the TFIIH core complex XPB subunit suppresses NF-κB and AP-1 signalling.

2020年12月9日 · 该研究旨在调查ercc3截短突变在一组疑似hboc患者中的作用。 研究人员对1311名散发患者的包含ERCC3在内的多个基因进行分析，以453名西班牙无癌个体和51,343名GonomAD非芬兰、非癌症欧洲个体为对照。