The K/HDEL receptor does not recycle but instead acts as a Golgi ...
2023年3月23日 · Here we demonstrate that ERD2 Golgi-retention, rather than fast ER export supports its function. Ligand-induced ERD2 redistribution is only observed when the C …
内质网和高尔基体的膜泡运输——货物蛋白的分拣与捕获 - 知乎
内质网 (ER)到高尔基体 (Golgi)的转运是蛋白分泌途径中的第一步。 内质网中的胞外蛋白和分泌通路中细胞器的蛋白被包装到囊泡，并运输到高尔基体。 细胞似乎可以区分天然和非天然蛋白 …
ERD2, a yeast gene required for the receptor-mediated retrieval …
1990年6月29日 · Here we describe ERD2, a gene required for retention. It encodes a 26 kd integral membrane protein whose abundance determines the efficiency and capacity of the …
Structural basis for pH-dependent retrieval of ER proteins from the ...
2019年3月8日 · The retrieval receptor ERD2 was discovered in 1990 as one of a number of ER retention defective (ERD) mutants in Saccharomyces cerevisiae (3 – 5). ERD2 encodes the 26 …
ERD2, a yeast gene required for the receptor-mediated ... - PubMed
1990年6月29日 · Here we describe ERD2, a gene required for retention. It encodes a 26 kd integral membrane protein whose abundance determines the efficiency and capacity of the …
<br>K/HDEL 受体不会循环利用，而是充当高尔基体看门人,Nature …
We propose that ERD2 remains fixed as a Golgi gatekeeper, capturing K/HDEL proteins when they arrive and releasing them again into a subdomain for retrograde transport back to the ER.
A KDELR-mediated ER-retrieval system modulates ... - ScienceDirect
2024年3月1日 · The increased mitochondrial respiration and reactive oxygen species production is required for cell survival in the absence of Erd2. Therefore, our findings reveal a novel role …
The ERD2 gene determines the specificity of the luminal ER …
1990年6月29日 · Indirect evidence suggests that HDEL is recognized by a receptor that retrieves ER proteins from the secretory pathway and returns them to the ER, and a candidate for this …
A KDELR-mediated ER-retrieval system modulates mitochondrial …
2024年2月14日 · KDELR (Erd2 [ER retention defective 2] in yeasts) is a receptor protein that retrieves endoplasmic reticulum (ER)–resident proteins from the Golgi apparatus. However, …
ERD2 proteins mediate ER retention of the HNEL signal of LRP's …
Our recent studies have demonstrated that RAP is an endoplasmic reticulum (ER) resident protein and an intracellular chaperone for the LDL receptor-related protein (LRP). The HNEL …