Ergoline is a core structure in many alkaloids and their synthetic derivatives. Ergoline alkaloids were first characterized in ergot. Some of these are implicated in the condition of ergotism, which can take a convulsive form [1] or a gangrenous form. Even so, many ergoline alkaloids have been found to be clinically useful.

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Ergoline is an indole alkaloid whose structural skeleton is found in many naturally occurring and synthetic ergolines which are known to bind to neurotransmitter receptors, such as dopamine, noradrenaline and serotonin receptors and function as unselective agonists or antagonists at these receptors. It is an ergoline alkaloid, a diamine, an ...

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The name “ ergoline ” is generic for the basic heterocyclic moiety of the alkaloids of the fungus, ergot (Claviceps purpurea). A simple derivative of ergoline, lysergic acid amide has recently been recognized in higher plants, as the hallucinogen of the seeds of Rivea corymbosa (Ololuiqui) and Ipomoea tricolor.