2022年4月13日 · IL-33 and its receptor ST2, as well as mast cells and their mediators, have been implicated in the development of chronic obstructive pulmonary disease (COPD). However, …

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Even before IL-33 binds to its receptor, its action could be altered by the decoy receptor soluble ST2 (sST2). sST2 is a variant of the full-length ST2 gene lacking the transmembrane and …

2021年2月18日 · In two pediatric PAH cohorts, elevated ST2 was associated with unfavorable pulmonary hemodynamics and functional measures, clinical worsening, and significantly …

ST2L is the biological receptor for IL-33, a member of the IL-1 family. IL-33 is the functional ligand of ST2L and signals the presence of tissue damage to local immune cells. IL-33/ST2L …

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