The inhibition of PPAR-γ or the activation of ERK blocked the induction of CD36 expression by OPG in cultured cells. Mechanistically, OPG facilitated CD36 expression by acting on PPAR response element (PPRE) present on the CD36 promoter.

2023年8月23日 · Upon binding with fatty acid, the CD36 molecules located on plasma membrane function as the initiator of CD36-Src-Akt/ERK signaling, which in turn activates Rac1 via Akt, and up-regulates...

2019年7月10日 · Mechanistically, OPG facilitated CD36 expression by acting on PPAR response element (PPRE) present on the CD36 promoter. Taken together, our study revealed that OPG signaling promotes liver steatosis through the ERK–PPAR-γ–CD36 pathway.

2024年6月1日 · COMP exerted fibrogenic function through its interaction with CD36 and activated MEK/ERK and PI3K/AKT signaling pathways. COMP could be a potential therapeutic candidate in the treatment of CP, and interfering with the communication between COMP and CD36 on PSCs may be the next direction for therapeutic research.

Herein, we review the role of CD36 in cancer progression, its participation in stemness control, as well as the efficacy of reported CD36 inhibitors in cancer cell cultures and animal models. Overall, the evidence compiled points that CD36 is a valid target for …

2018年12月1日 · Pretreatment of HeLa cells with an Src kinase inhibitor largely blocked the tumor-promoting effect of OA. Our findings suggest that dietary OA exerts a stimulatory effect on CC growth and metastasis, and CD36 might be a promising therapeutic target that acts against CC through an Src/ERK-dependent signaling pathway.

2019年7月10日 · The stimulatory role of OPG in lipid accumulation was blocked by CD36 inactivation in hepatocytes isolated from CD36 −/− mice. The overexpression of OPG led to a decrease in extracellular signal–regulated kinase (ERK) phosphorylation in the livers of OPG −/− mice and in cultured cells, while OPG deficiency resulted in the opposite effect.

2018年9月19日 · Mechanistically, CD36 receptor played an essential role in COMP-mediated HCC cell proliferation and metastasis. Functionally, COMP/CD36 signaling caused phosphorylation of ERK and AKT, resulting in the upregulation of tumor-progressive genes such as EMT markers, MMP-2/9, Slug and Twist in HCC cells.

2023年7月25日 · Mechanistically, Orm2 deletion activates the Erk1/2-PPARγ-Cd36 signaling pathway, increasing fatty acid uptake and absorption in hepatocytes and mice. Overall, our …

2024年3月11日 · 进一步，RNA-seq组学分析和体外验证实验表明，rCOMP能够显着促进HPSCs的增殖和活化，这可能是由于通过膜蛋白受体CD36促进ERK和AKT的磷酸化。 rCOMP 同时增加 HPSC 中 α-SMA、纤连蛋白和 I 型胶原蛋白的表达。 总之，本研究表明COMP在CP纤维化组织中上调，并且COMP通过CD36-ERK/AKT信号通路诱导PSC的活化、增殖和迁移。 COMP 可能是治疗 CP 的潜在候选药物。 干扰 PSC 上 COMP 的表达或 COMP 与 CD36 之间的通讯可能是治 …