2023年2月13日 · Here, we identified MAPK/ERK kinase (MEK) 1, a central component of the ERK pathway, as a specific substrate for the executioner caspase-3. During apoptosis, MEK1 is cleaved at an evolutionarily conserved Asp282 residue in the kinase domain, thereby losing its catalytic activity.

2021年9月8日 · TRIM15 and CYLD regulate ERK ubiquitination at defined lysine residues through mutually exclusive interactions as well as opposing activities. K63-linked polyubiquitination enhances ERK...

2018年4月9日 · The ERK (extracellular-signal-regulated kinase) signaling controls several cellular processes such as cell growth, proliferation, differentiation and apoptosis. The ERK signaling pathway considered in this work starts with an extracellular stimulus and ends with activated (double phosphorylated) ERK which gets translocated into the nucleus.

Active ERK can translocate to the nucleus, where it stimulates gene expression, or dimerize and phosphorylate cytoplasmic substrates. Depending on ERK dynamics, several gene expression programs can be activated, including cell cycle, cell survival, and ligand production (pathways bolded and specific genes listed in the box within the nucleus).

ras/raf/mapk（mek）/erk通路是所有mapk信号传导途径中最重要的信号级联，对肿瘤细胞的生存和发展起着关键作用。 TargetMol MAPK 抑制剂库是有367 个 MAPK 信号通路相关的小分子的集合，可用于研究 MAPK 信号通路及相关疾病药物筛选。

Cleavage of KSR1 destroys its ERK scaffolding potential, results in the generation of a stable C-terminal fragment that can inhibit ERK signaling, and correlates with a pronounced reduction in active phosphoERK levels.

2013年11月22日 · Through PAR-1 cleavage SpeB efficiently blunted thrombin-induced induction of the ERK-pathway in endothelial cells and prevented platelets aggregation in response to thrombin. Conclusions/significance: Our results identify a novel function of the streptococcal virulence factor SpeB.

Here, we identified MAPK/ERK kinase (MEK) 1, a central component of the ERK pathway, as a specific substrate for the executioner caspase-3. During apoptosis, MEK1 is cleaved at an evolutionarily conserved Asp282 residue in the kinase domain, thereby losing its catalytic activity.

2004年1月2日 · Here we show that p53 can directly counteract the Ras/MAPK signaling by inactivating ERK2/MAPK. This inactivation is due to a caspase cleavage of the ERK2 protein and contributes to p53-mediated...

2020年7月7日 · We investigated the mechanism that makes ERK resistant to NleD cleavage. Biochemical and structural analyses revealed that NleD exclusively targets activation loops with high conformational flexibility. Accordingly, NleD cleaved the flexible loops of JNK and p38 but not the rigid loop of ERK.