2024年4月18日 · 血流流动中的 ECs 通过 MIEN1 和细胞骨架重塑进行机械传感，导致细胞质信号激活（ERK/MAPK信号），从而改变 VEGFB 的表达，调节血管生成。

Here, we established mice with CMG2 only expressed in tumor endothelial cells (ECs) and determined the specific contribution of tumor stromal ECs to the toxin’s antitumor activity. Our results demonstrate that disruption of ERK signaling …

ERK activation, regulated by RAF1-AKT crosstalk, controls SOX18 and PROX1 expression in venous ECs, which leads to delamination of these LEC progenitors and eventually to full LEC fate specification.

We demonstrate that the Epac agonist 8-CPT-cAMP activates PI3Kα and PI3Kβ signalling which regulates the EC survival but not its EC barrier stabilising actions. Moreover, it also activates MEK/ERK signalling and pharmacological inhibition of which enhances the Epac agonist-mediated EC barrier stabilising effects.

2007年3月1日 · Using pre-conditioned ECs, we revealed the presence of a mechanism, which we call ISE, that down-regulates ERK phosphorylation in a CS- and tyrosine phosphatase-dependent manner, and this occurs in the face of increased MEK phosphorylation.

Expression of mutant RAF1 (S259A) in ECs activated ERK and induced SOX18 and PROX1 expression, leading to increased commitment of venous ECs to the lymphatic fate. Excessive production of lymphatic ECs resulted in lymphangiectasia that was highly reminiscent of abnormal lymphatics seen in Noonan syndrome and similar "RASopathies."

Here, we demonstrated that hypoxia promoted BMSCs proliferation, colony formation, osteogenic markers expression, mineralization, and extracellular signal-regulated protein kinase (ERK) phosphorylation, and that PD98059 (ERK inhibitor) blocked …

1998年9月1日 · We demonstrated age-dependent changes in MAPK activation induced by shear stress using in vitro propagated ECs. Our findings indicate that the alteration in cellular membrane may be responsible for decreased ERK2 activity in shear-stressed ECs.

2024年4月1日 · Endothelial cells (ECs) senescence is critical for vascular dysfunction, which leads to age-related disease. DHCR24, a 3β-hydroxysterol δ 24 reductase with multiple functions other than enzymatic activity, has been involved in age-related disease.

丝裂原活化蛋白激酶 (MAPKs)，包括ERK、JNK和p38，在细胞生长、迁移、增殖、分化和凋亡中发挥关键作用。 MAPK/Erk通路主要由GTP结合的Ras激活Raf而启动。 Raf使Mek磷酸化，而Mek又使Ras-Raf-Mek-Erk信号级联的主要组分Erks磷酸化。