2023年12月1日 · Simo-Cheyou and colleagues found that Ang II induces Egr-1 through Ca 2+ /ERK-dependent cAMP-response element binding protein (CREB) activation. These data demonstrate the involvement of PKA-mediated suppression of Ang II-inducible ERK phosphorylation and Egr-1 expression and helps explain how cAMP mediates its vasculoprotective effects [92].

2020年6月23日 · We begin with a brief overview of the structure, regulation, substrate recognition and subcellular localization of ERK1 and ERK2. We then systematically discuss how ERK signalling regulates six...

2012年1月24日 · The importance of the ERK pathway for transcriptional activation of the EGR1 promoter was verified using the MEK inhibitor PD98059, which reduced EGR1 promoter activity in both −1,260 hEGR1 and −771 hEGR1 constructs by ~80% in LNCaP cells and 55% and 36% in PC3 cells relative to the activity in the presence of EGF alone.

2023年9月20日 · CVD 发病机制的多个分子和细胞过程受到锌指转录因子和即早期基因早期生长反应 1 (Egr-1) 的产物的调节。 Egr-1 调节多种促炎过程，这些过程是 CVD 表现的基础。

2021年11月10日 · Inducible Egr‐1 expression is reliant upon the activity of extracellular signal‐regulated kinase (ERK), c‐Jun N‐terminal kinase, p38 kinase, protein kinase A, protein kinase B and protein kinase C. Egr‐1 interacts with recognition elements in promoter/enhancer regions of responsive genes, including platelet‐derived growth factor ...

The MAPK–ERK pathway is a classic proliferation signaling cascade that is triggered by growth factors. In C6 cells, estrogen receptor β (ERβ) can launch the RAF–MEK1–ERK–ELK1 signaling pathway and upregulate EGR1 .

2019年3月1日 · In certain cell types, EGR1 expression is highly induced in response to ER stress. The enhancement of EGR1 abundance results from increased transcription. The signaling that leads to increased EGR1 transcription is the MEK-ERK pathway. The transcription factors ELK1 and EGR1 contribute to the cellular ER stress response.

2006年8月8日 · Both VV and CPV stimulate the MEK/ERK/EGR-1 pathway from early until late times of viral infective cycle. Upon stimulation, EGR-1 translocates into the nucleus where it binds to the regulatory region (EBS) of EGR-1-regulated genes to control their expression.

Analysis provided evidence for a SRC-RAS-RAF-MEK-ERK cascade mechanism that leads to enhanced phosphorylation of the transcription factor ELK1. ELK1 and serum response factor (SRF) are constitutively bound to the EGR1 promoter and …

Multiple molecular and cellular processes underpinning the pathogenesis of CVD are regulated by the zinc finger transcription factor and product of an immediate-early gene, early growth response-1 (Egr-1). Egr-1 regulates multiple pro-inflammatory processes …