2015年2月12日 · MEK, as a central nexus, both conveys upstream stimuli and governs two discrete but interconnected downstream effector pathways, of which one is mediated by ERK and the other by HSF1 (Figure 7H). In a negative feedback fashion, ERK finely attunes HSF1 activation via inhibitory phosphorylation of MEK (Figure 7H). While our studies focused on MEK ...

From these data we propose a unique model whereby the ERK-1/2-dependent activation of HSF1 promotes chemotherapeutic resistance to benzimidazole carbamates. Therefore, targeting the ERK-1/2 signaling cascade is a potential strategy for HSF1 inhibition and a means of enhancing the cytotoxicity of these agents.

2004年11月19日 · We have examined the interaction of two key molecular components in the response, heat shock transcription factor 1 (HSF1) and extracellular signal regulated protein kinase (ERK). Whereas both HSF1 and ERK are required to protect cells against apoptosis, ERK activation is paradoxically antagonistic to trans-activation of hsp promoters by HSF1 ...

2004年11月19日 · We have examined the interaction of two key molecular components in the response, heat shock transcription factor 1 (HSF1) and extracellular signal regulated protein kinase (ERK). Whereas both HSF1 and ERK are required to protect cells against apoptosis, ERK activation is paradoxically antagonistic to trans-activation of hsp promoters by HSF1 ...

Heat stress expression patterns of HSP90, as well as the expression and phosphorylation levels of extracellular-regulated signal kinases (ERKs) and the transcription factor HSF1 and c-Fos, were examined. The results show that heat stress activates ERK1/2 and HSF1, and induces HSP90 gene expression in TK cells.

ANG II activates ERK/GSK3 to phosphorylate HSF1, resulting in RNF126 degradation, which stabilizes IGF-IIR protein expression and eventually results in cardiac hypertrophy. HSF1 could be a valuable therapeutic target for cardiac diseases among hypertensive patients.

2020年5月26日 · Heat-shock factor 1 (HSF1) is a master regulator of the heat-shock response and facilitates cell survival and proliferation in eukaryotes. It has been widely reported...

2024年11月30日 · HSF1 is involved in the regulation of interaction with TME by activating specific programs in both cancer and stroma cells (A); it enhances the migration and invasion ability of cancer cells by EMT program activation (B); it can promote higher proliferating activity by Ras/Raf/MEK/ERK signaling (C); participation of HSF1 in apoptotic pathways ...

2017年8月30日 · Heat shock transcription factors (HSFs) have broad roles in stress resistance that encompass protection from protein misfolding, inflammation and environmental insults. Structural...

2016年9月23日 · In this study, we demonstrated that H 2 O 2 induces BIS phosphorylation via ERK, which has a role in the regulation of HSF1 nuclear translocation likely by altering its binding affinity with...