The MEK1/2-ERK Pathway Inhibits Type I IFN Production in
2018年2月26日 · These results indicate that the MEK1/2-ERK pathway inhibits TLR9-mediated type I IFN production in pDCs and that pharmacological targeting of MEK1/2-ERK signaling …
The balance between IFN-γ and ERK/MAPK signaling activities …
2025年2月13日 · Using in vivo phenotypic analysis, transcriptomics, and in vitro intestinal organoid studies, we show that age-dependent activation of interferon-γ (IFN-γ) signaling and …
ERK is a negative feedback regulator for IFN-γ/STAT1 signaling by ...
2018年5月31日 · In this paper, we have reported that the ERK negatively regulated IFN-γ signaling by ubiquitination of STAT1 in ESCC cells. We also found that MG132 induced …
IL-6/ERK signaling pathway participates in type I IFN ... - Nature
2023年2月1日 · The present work establishes a role of IL-6/ERK signaling in promoting M2-like macrophage polarization, and suggests this axis as a potential therapeutic target for …
Frontiers | The MEK1/2-ERK Pathway Inhibits Type I IFN …
2018年2月25日 · Our results suggest that the MEK1/2-ERK-dependent expression and phosphorylation of c-FOS exerts an intrinsic block of TLR9-mediated production of type I IFN. …
DUSP4 modulates RIG-I- and STING-mediated IRF3-type I IFN …
2024年2月21日 · We found that DUSP4 regulates the activation of TBK1 and ERK1/2 in a signalling complex containing DUSP4, TBK1, ERK1/2 and IRF3 to regulate the production of …
The IFN-γ–p38, ERK kinase axis exacerbates neutrophilic chronic ...
2019年2月25日 · We further demonstrated that IFN-γ induced the EMT via the p38 and extracellular signal-regulated kinase (ERK) pathways in a manner distinct from the hypoxia …
ERK is integral to the IFN-γ-mediated activation of STAT1, the ...
2010年9月1日 · These studies suggest a critical role for ERK signaling in the IFN-gamma-mediated changes in macrophage cholesterol homeostasis and gene expression during …
ERK is a negative feedback regulator for IFN-γ/STAT1 ... - PubMed
2018年5月31日 · To conclude, ERK is an effective negative regulator of STAT1 signaling in ESCC, by promoting its proteasome degradation and decreasing IFNγ production. Our data …
ERK Is Integral to the IFN-γ–Mediated Activation of STAT1, the ...
2010年9月1日 · We demonstrate a crucial role for ERK in the IFN-γ–induced STAT1 activation, associated changes in macrophage gene expression relevant to atherosclerosis, and the …