2024年4月18日 · Our results demonstrate that the ER stress sensor IRE1 helps to sustain PERK expression during chronic ER stress. This occurs through a mechanism facilitated by IRE1-XBP1s signaling, with IRE1-RIDD...

2019年2月18日 · Here, we report that the adaptive signalling of the unfolded protein response, IRE1α–XBP1, protects HSCs from endoplasmic reticulum stress-induced apoptosis. IRE1α knockout leads to reduced...

2020年8月8日 · IRE1α首先发生磷酸化，并形成二聚体。 p-IRE1α接下来会催化一个重要的过程：使Xbp1 mRNA发生剪切，形成一个功能活跃的转录因子Xbp1s。 Xbp1s进入细胞核后会启动一系列基因转录 (如脂质合成、ERAD等)，从多个层次缓解内质网应激。 除此之外p-IRE1α可以通过RIDD过程促进mRNA的降解，减缓新生多肽链合成，降低内质网压力。 （这个过程是不是很像学校（内质网）丧心病狂的把幼儿园的小孩（mRNA）全灭了，来年肯定没有新生（多肽链）入 …

2016年4月7日 · Mammalian inositol-requiring enzyme 1α (IRE1α) is the most conserved of all endoplasmic reticulum (ER) stress sensors, which includes activating transcription factor (ATF) 6 and...

2019年12月15日 · Master regulators of the unfolded protein response (UPR), IRE1α and PERK, promote adaptation or apoptosis depending on the level of endoplasmic reticulum (ER) stress. Although the UPR is activated in many cancers, its effects on tumor growth remain unclear.

2022年8月1日 · Endoplasmic reticulum (ER) stress can be induced by various stimuli and triggers the unfolded protein response to activate intracellular signaling pathways that are mediated by 3 ER-resident sensors: inositol requiring protein-1α (IRE1α), PKR-like ER kinase (PERK), and activating transcription factor-6 (ATF6).

Inositol-requiring transmembrane kinase endoribonuclease-1α (IRE1α) is the most prominent and evolutionarily conserved unfolded protein response (UPR) signal transducer during endoplasmic reticulum functional upset (ER stress). A IRE1α signal pathway arbitrates yin and yang of cellular fate in objectionable conditions.

2018年6月6日 · Inositol-requiring transmembrane kinase/endoribonuclease 1α (IRE1α) is the most prominent and evolutionarily conserved endoplasmic reticulum (ER) membrane protein. This transduces the signal of misfolded protein accumulation in the ER, named as ER stress, to the nucleus as “unfolded protein response (UPR).”

2024年5月7日 · Here we report that, in mammalian cells, formation of IRE1α clusters is an ER membrane-bound phase separation event that is coupled to the assembly of stress granules (SGs). In response to...

also enabled the identification of IRE1a phosphorylation sites by extracellular signal-regulated kinase (ERK) at speci fic sites, such as T973, S525, S529, and S549. Collectively, an array of receptor tyrosine kinases (RTKs), directing ERK and AKT activity in various KRASi-resistant tumors, consistently converge in regulating IRE1a (Figure 1C).