快速了解ERK/MAPK信号通路？ - 知乎专栏
在真核细胞中已经确定了以下四条MAPK级联途径：ERK、 JNK 、 p38 MAPK 和ERK5信号转导途径。 今天我们来快速了解一下ERK/MAPK信号通路。 ERK是一种丝氨酸/苏氨酸蛋白激酶，是 …
学懂通路第三期： MAPK信号通路 - 知乎 - 知乎专栏
ERK激酶是MEK激酶的唯一下游靶点，研究显示，靶向于ERK靶点的抑制剂能够有效阻断RAS-RAF-MEK-ERK信号通路，同时能够有效逆转由上游BRAF、MEK突变而导致的耐药。 目 …
层层进击的磷酸化信号—MAPK通路解析 (下) - 知乎
JNK/SAPK (c-Jun kinase/stress activated protein kinase)级联反应能被UV辐射、热激或者炎症因子激活。 如下图，举例其中一个途径： 这类MAPK通路可以由两种小G蛋白Rac和Cdc42介导。
The ERK and JNK pathways in the regulation of metabolic
2018年11月28日 · In this review, we summarize our current understanding of the roles of the ERK and JNK pathways in controlling the Warburg effect in cancer and discuss their implication in …
MAPK signal pathways in the regulation of cell proliferation in ...
2002年3月1日 · MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. At least three MAPK …
The ERK and JNK pathways in the regulation of metabolic
In this review, we summarize our current understanding of the roles of the ERK and JNK pathways in controlling the Warburg effect in cancer and discuss their implication in controlling …
ERK signalling: a master regulator of cell behaviour, life and fate
2020年6月23日 · We begin with a brief overview of the structure, regulation, substrate recognition and subcellular localization of ERK1 and ERK2. We then systematically discuss how ERK …
Differential regulation of c‐Jun by ERK and JNK during PC12 cell ...
1998年8月3日 · The two MAP kinases JNK and ERK direct distinct cellular activities even though they share a number of common substrates, including several transcription factors. Here we …
Targeting MAPK-ERK/JNK pathway: A potential intervention …
2024年4月1日 · This review focuses on the treatment of myocardial fibrosis, thoroughly exploring the central role of the MAPK-ERK/JNK pathway and detailing various potential inhibitors that …
Pathological roles of MAPK signaling pathways in human diseases
Persistent activation of the JNK or p38 signaling pathways has been suggested to mediate neuronal apoptosis in AD, PD, and ALS, whereas the ERK signaling pathway plays a key role …