通常认为c-Myc激活能够诱导人类肿瘤的发生，所以严格调控c-Myc至关重要。 c-Myc的表达由有丝分裂信号诱导并由生长抑制信号抑制。 c-Myc的主要调节作用是通过与Max蛋白结合发生的。

2023年7月18日 · We identified ERK2 binding sites in the MYC promoter and detected ERK2 at the promoter in various serum-stimulated cell types. Expression of nuclear-localized ERK2 constructs in serum-starved cells revealed that ERK2 in the nucleus—regardless of its kinase activity—increased MYC mRNA expression and MYC protein abundance.

2020年6月23日 · The ERK-activated transcription factors MYC and hypoxia-inducible factor 1α (HIF1α) jointly stimulate the expression of glucose transporters and glycolysis enzymes, thus increasing...

AP-1可调控myc的表达，myc作为转录因子，调控众多与细胞增殖、代谢和凋亡相关的基因表达，进而促进细胞的生长和分裂。 细胞外信号经过信号传导链的层层传递，激活细胞核中的转录因子后，启动和细胞周期控制相关的基因表达，使细胞增殖。

2006年8月9日 · We demonstrate that, in all the tumor cell lines used, the MEK/ERK inhibitor U0126 rapidly induces c-Myc de-phosphorylation, which is followed by a marked reduction in its expression level, by inhibition of proliferation and by reversion of anchorage-independent growth.

2012年5月15日 · Here we show that ADI-PEG20 activates Ras signaling and the effector extracellular signal-regulated kinase (ERK) and phosphoinositide 3-kinase (PI3K)/AKT/GSK-3β kinase cascades, resulting in phosphorylation and stabilization of c-Myc by attenuation of its ubiquitin-mediated protein degradation mechanism.

We discovered that c-Myc is a downstream effector of ERK signaling and that the MEK–ERK–c-Myc central metabolic axis in tumor ECs is essential for tumor progression. As such, disruption of ERK–c-Myc signaling in host-derived tumor ECs by our tumor-selective anthrax toxins explains their high efficacy in solid tumor therapy.

活化的ERK可以磷酸化一些核内的转录因子如c-fos、c-Jun、Elk-1、c-myc和ATF2等，从而直接参与细胞增殖与分化的调控。它也可靶向p90-RSK(核糖体S6激酶)等底物间接调控基因表达。

2024年11月8日 · Activation of MEK-ERK-c-MYC signaling pathway promotes splenic M2-like macrophage polarization to inhibit PHcH-liver cirrhosis. Therefore, the induction of macrophage depolarization might represent a new therapeutic approach in the cure of PH hypersplenism, making c-Myc a potential candidate for mac …

2013年8月27日 · 最近，国外学者又新克隆出ERK5及其上游激酶MEK5，这条MAPKs信号通路 可被H2O2及高渗刺激活 [2]，其底物为c-Myc。 通过分子生物学技术发现还有ERK3 Kinase/ERK3及ERK4两条通路存在，但目前对其激活信号、底物及生物学意义还不清楚。 MAPK信号通路专题MAPK,丝裂原活化蛋白激酶 (mitogen-activatedproteinkinases，MAPKs)是细胞内的一类丝氨酸/苏氨酸蛋白激酶。 研究证实，MAPKs信号转导通路存在于大多数细胞内，在将细胞外刺激信号 …