2023年8月14日 · This study aimed to explore the molecular function changes of ERK-Drp1/Mfn2-autophagy signaling pathway in SH-SY5Y cell oxygen-glucose deprivation/reoxygenation (OGD/R) model, to further clarify the pathophysiological mechanism of CIRI, and to provide a new strategy for cerebral protection after CIRI.

2022年10月29日 · Increased expression of Mfn2 triggers AMPK, promotes autophagy, reduces ROS, and suppresses OC progression by downregulating the p-mTOR (2481 and 2448) and p-ERK axis. OC patients with higher Mfn2 expression …

We determined that increased Mfn2 promotes autophagy, reduces ROS levels, and thus suppresses OC cell growth by activating the AMPK/mTOR-S2481/ERK signaling pathway. We also determined that increased Mfn2 expression reduces OC cell migration and invasion by reducing epithelial-to-mesenchymal transition (EMT) and F-actin remodeling.

Mfn2 表达增加会触发 AMPK，促进自噬，降低 ROS，并通过下调 p-mTOR（2481 和 2448）和 p-ERK 轴来抑制 OC 进展。 Mfn2 表达较高的 OC 患者比 Mfn2 水平较低的 OC 患者生存率更高。

2017年2月8日 · We find that MFN2 knockout from MCF7 and A549 cells via Crispr/Cas9 greatly promotes cell viability, colony formation, and invasion of cancer cells in vitro and in vivo, which were confirmed by...

2022年11月1日 · RAS-RAF-ERK1/2 pathway involves in MFN2-mediated VSMC calcification. Vascular calcification (VC), as a prevalent feature of atherosclerosis (AS), is a life-threatening pathological change. Mitofusin 2 (MFN2) has been reported to be down-regulated and participate in the pathogenesis of AS. Here, we explored the feasible impacts of MFN2 on VC in AS.

PD98095能抑制MFN2敲低后p-ERK通路的激活,增加了MCF-7细胞的促凋亡作用,从而逆转了MFN2敲低后乳腺癌细胞的抗凋亡.4. MFN2为抑癌基因,负向调节p-ERK的表达,并在雌激素的作用下具有一定促凋亡作用.

Knockdown of NR4A1 elevated Mfn2 expression and therefore reversed mitophagic activity, sending a prosurvival signal for mitochondria in the setting of cerebral IR injury. Further, we demonstrated that NR4A1 modulated Mfn2 expression …

2023年10月16日 · We investigated the role of MFN2 in renal cancer cells using CCK 8, clone formation, wound healing assay, and methylase qPCR experiments.

2018年11月1日 · Mfn2, a novel downstream effector of Sirt1, enhances mitochondrial function through multiple effects [46]. Additionally, the MAPK-ERK axis, a classic anti-apoptotic signalling pathway, is activated by Sirt1 and protects the mitochondria from oxidative stress, hypoxia and the inflammatory response.