2020年6月23日 · We begin with a brief overview of the structure, regulation, substrate recognition and subcellular localization of ERK1 and ERK2. We then systematically discuss how ERK signalling regulates six...

2020年11月9日 · FGF/ERK signaling is crucial for the patterning and proliferation of cell lineages that comprise the mouse blastocyst. Using an ERK-kinase translocation biosensor, Simon et al. show that the trophectoderm is patterned by spatially graded ERK activity and that primitive endoderm and epiblast cells have distinct ERK dynamics.

2019年11月6日 · Fibroblast growth factor-extracellular signal-regulated kinase (FGF -ERK) signalling drives differentiation of mouse embryonic stem cells (ES cells) and pre-implantation...

2023年6月10日 · In this study, we established mouse ESC lines expressing the FRET biosensor EKAREV-NLS, and measured ERK signaling activity in individual ESCs in maintenance and differentiating conditions.

Arekatla et al. use optogenetics to control ERK and AKT dynamics in mouse embryonic stem cells. Cumulative ERK activity over time—not duration, amplitude, or types of dynamics—induces pluripotency exit, and lower AKT activation, at constant ERK activity, contributes to higher pluripotency exit.

MEK (mitogen-activated protein kinase) inhibitor is widely used for culturing pluripotent stem cells, while prolonged MEK inhibition compromises the developmental potential of mouse embryonic stem cells (ESCs), implying a dual role of MEK/ERK (extracellular signal-regulated kinase) signaling in plur …

The E18.5 scATAC-Seq and P1 mouse cortical scRNA-seq data were from our previous study , GSE161132. ... L. B. Corson, Y. Yamanaka, K. M. Lai, J. Rossant, Spatial and temporal patterns of ERK signaling during mouse embryogenesis. Development 130, …

2015年2月10日 · Extracellular signal-regulated kinase (ERK) is a key effector of many growth signalling pathways. In this study, we visualise epidermal ERK activity in living mice using an ERK FRET biosensor.

2015年11月3日 · Here we demonstrate that Erk signaling is critical for mouse ESC self-renewal and genomic stability. Erk-depleted ESCs cannot be maintained. Lack of Erk leads to rapid telomere shortening and genomic instability, in association with misregulated expression of pluripotency genes, reduced cell proliferation, G1 cell-cycle arrest, and increased ...

FGF/ERK signaling is crucial for the patterning and proliferation of cell lineages that comprise the mouse blastocyst. Using an ERK-kinase translocation biosensor, Simon et al. show that the trophectoderm is patterned by spatially graded ERK activity and that primitive endoderm and epiblast cells have distinct ERK dynamics.