2020年6月23日 · In this Review, we discuss the current understanding of this important class of kinases. We begin with a brief overview of the structure, regulation, substrate recognition and subcellular...

Top, epidermal growth factor (EGF) binds to the EGF receptor (EGFR) in the cell membrane, starting the cascade of signals. Further downstream, phosphate signal activates MAPK (also known as ERK). Bottom, signal enters the cell nucleus and causes transcription of DNA, which is then expressed as protein.

ERK是extracellular regulated protein kinases的英文缩写，指细胞外调节蛋白激酶，包括ERK1和ERK2，是将信号从表面受体传导至细胞核的关键。许多其他信号通路明显活化时，可活化蛋白激酶ERK信号通路，ERK明显活化时，也可活化其他信号通路。

Extracellular signal-regulated kinase (ERK) is a member of the mitogen-activated protein kinase family of signaling molecules. ERK is predominantly found in two forms, ERK1 (p44) and ERK2 (p42), respectively. There are also several atypical forms of …

RAS/RAF/MEK/ERK便是与癌症相关的信号通路中最经典的一条。 细胞膜外的是配体，与之相结的是位于细胞膜上的是受体，如EGFR、HER2、FGFR、VEGFR等。 可关注公众号“基因APP”，查看既往文章。 RAS蛋白有两种状态：激活状态和失活状态，当RAS与GTP结合时，RAS 处于激活状态，并向下游传递激活信号；当RAS与GDP结合时，RAS处于失活状态，无法激活下游通路。 激活过程：细胞外的生长因子等配体与 RTKs 结合后，会引起受体的二聚化和自身磷酸化。 …

ERK1/2 are proline-directed kinases that preferentially catalyze the phosphorylation of substrates containing a Pro-Xxx-Ser/Thr-Pro sequence. Besides this primary structure requirement, many ERK1/2 substrates possess a D-docking site, an F-docking site, or both.

In molecular biology, extracellular signal-regulated kinases (ERKs) or classical MAP kinases are widely expressed protein kinase intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells.

2012年8月1日 · ERK1/2 are proline-directed kinases that preferentially catalyze the phosphorylation of substrates containing a Pro-Xxx-Ser/Thr-Pro sequence. Besides this primary structure requirement, many ERK1/2 substrates possess a …

ERK1/2是 RAF-MEK-ERK信号通路 的关键组成部分，在 Thr202 、 Tyr204 位点被磷酸化从而激活，进而激活多种与细胞增殖、分化、迁移和血管生成相关的底物（超过160种）。因此ERK1/2的(Thr202, Tyr204)/(Thr185, Tyr187)磷酸化是ERK激活的关键步骤，也是相关研究中不可或缺的检测 ...

2021年5月20日 · ERK为细胞外信号调节激酶（extracellular signal-regulated kinase, ERK），其广泛存在于胞浆中，含有丝氨酸/苏氨酸残基的蛋白质激酶，目前已发现共5个亚族，该激酶是丝裂原活化蛋白激酶（MAPKs）信号转导系统组成…