2013年9月17日 · We developed a dynamical model to study the effects of phosphodiesterase 4 (PDE4), a cAMP phosphodiesterase that is phosphorylated and inhibited by ERK, on the membrane insertion of AMPAR. The model predicted that PKA could be a downstream effector of ERK in regulating AMPAR insertion.

2019年6月17日 · The growth-promoting kinase Erk is able to phosphorylate a serine at the C-terminal end of the conserved PDE4 core catalytic domain of isoforms of PDE4B, PDE4C, and PDE4D, but not PDE4A forms .

We developed a dynamical model to study the effects of phosphodiesterase 4 (PDE4), a cAMP phosphodiesterase that is phosphorylated and inhibited by ERK, on the membrane insertion of AMPAR. The model predicted that PKA could be a downstream effector of ERK in regulating AMPAR insertion.

2004年4月28日 · These results suggest that MEK/ERK signaling plays an inhibitory role in regulating PDE4 activity in the brain; this may be a novel mechanism by which MEK/ERK signaling mediates memory....

ERK inhibition of long isoforms is regulated by a unique feedback control whereby elevated cAMP levels cause PKA (protein kinase A) to phosphorylate UCR1 and ablate the inhibitory action of ERK. PDE4 isoforms can also be found in complex with beta-arrestins where they provide a novel part of the cellular desensitization mechanism to receptor ...

2013年8月28日 · We have identified the motif of ERK inhibiting PDE4 and controlling PKA output as a key step in the dopamine-induced membrane trafficking of GluA1. The significance of this regulatory motif is that it provides a point of integration for ERK activating signals to modulate neuronal excitability by tuning the trafficking of AMPAR.

2014年11月4日 · 已有研究证实， pde4 和 erk 为camp/pka/creb 信号通路的调节蛋白。 现对 cAMP/PKA/CREB 信号通路中的各蛋白及其调控蛋白PDE- 4 和 ERK 进行研究，阐述着三者之间的关系，并探讨其对学习记忆的影响。

2013年8月28日 · We have identified the motif of ERK inhibiting PDE4 and controlling PKA output as a key step in the dopamine-induced membrane trafficking of GluA1. The significance of this regulatory motif is that it provides a point of integration for ERK activating signals to modulate neuronal excitability by tuning the trafficking of AMPAR.

2003年2月15日 · PDE4 isoforms are 'designed' to be regulated by extracellular-signal-related protein kinase (ERK), which binds to anchor sites on the PDE4 catalytic domain that it phosphorylates. The upstream conserved region 1 (UCR1) and 2 (UCR2) modules that abut the PDE4 catalytic unit confer regulatory functions by orchestrating the functional outcome of ...

2014年2月10日 · PDE-4和ERK进行研究，阐述着三者之间的关系，并探讨其对学习记忆的影响。 关键词：环磷酸腺苷；环磷酸腺苷反应元件结合蛋白；磷酸二酯酶4；细胞外信号调节激酶；学习记忆. InfluenceofLearningandMemoryontheExpressionofRelevantControllingProteinPDE-4and. ExtracellularSignalRegulatingKinaseYANGXia. ，PENGSheng. ，LIUGong-Jian. ．（1．XuzhouMedical.