Here, we demonstrate that the ERK-activated kinase RSK is necessary to induce motility and invasive capacities in non-transformed epithelial cells and carcinoma cells. RSK is moreover …

2020年6月23日 · ERK-activated kinases of the ribosomal protein S6 kinase (RSK), mitogen- and stress-activated protein kinase (MSK) and MAPK-interacting kinase (MNK) families …

The 90 kDa ribosomal S6 kinase (RSK) family of proteins is a group of highly conserved Ser/Thr kinases that are downstream effectors of the Ras–extracellular signal-regulated kinase...

Signaling via extracellular regulated kinase 1/2 (ERK1/2) and p90 ribosomal S6 kinase (RSK), a downstream effector, mediates numerous processes. For example, ERK1/2-RSK signaling is …

2009年8月28日 · We demonstrate that the ERK-activated kinase RSK is necessary to induce mesenchymal motility and invasive capacities in nontransformed epithelial and carcinoma …

We demonstrate that members of the erk-encoded family of mitogen-activated protein (MAP) kinases (pp44/42mapk/erk) and members of the rsk-encoded protein kinases (RSKs or …

3 天之前 · FGFR1, SPRED2, GAB3 and CNKSR2 act upstream of RSK in the RAS-ERK MAP kinase pathway. Analysis of ERK activation in cells expressing a mutated form of RSK lacking …

活化的ERK的靶点包括p90核糖体S6激酶 (RSK)和细胞质磷脂酶A2（cPLA2）。 ERK也会入核，磷酸化转录因子 Elk-1 (383位和389位的丝氨酸)。 通常只有一种高度活化的ERK1或ERK2存在 …

2013年12月1日 · ERK and RSK regulate distinct steps of morphological changes in epithelial cells. ERK, but not RSK, induces loss of apical–basal polarity. RSK induces the destabilization …

2009年8月28日 · We demonstrate that the ERK-activated kinase RSK is necessary to induce mesenchymal motility and invasive capacities in nontransformed epithelial and carcinoma …