2020年6月23日 · Chromatin immunoprecipitation experiments have revealed signalling-dependent association of ERK with promoters of RAS–ERK pathway target genes in conjunction with RNA polymerase II (Pol II)...

Classical biochemical and genetic approaches have elicited hundreds of direct ERK substrates, and with the advent of phospho-proteomic technologies, numerous studies have expanded the number of ERK target proteins.

Downstream Targets of ERK Signaling. ERK1 and ERK2 positively regulate transcription directly and indirectly via phosphorylation of ribosomal protein S6 kinases (RSKs), mitogen- and stress-activated protein kinases (MSKs), and ternary complex factors (TCFs).

2017年7月4日 · Classical biochemical and genetic approaches have elicited hundreds of direct ERK substrates, and with the advent of phospho-proteomic technologies, numerous studies have expanded the number of ERK target proteins.

2023年4月26日 · Specifically, we interrogated the ERK database to identify a common set of ERK targets that are positively regulated in response to injury during regeneration and down-regulated upon FGFR, ErbB-2, and ERK inhibition .

Here, we report identification and activity of LY3214996, a potent, selective, ATP-competitive ERK inhibitor. LY3214996 treatment inhibited the pharmacodynamic biomarker, phospho-p90RSK1, in cells and tumors, and correlated with LY3214996 exposures and antitumor activities.

2009年9月20日 · Using a phosphoproteomic approach combining the steroid receptor fusion system, IMAC, 2D-DIGE and phosphomotif-specific antibodies, we detected 38 proteins showing reproducible phosphorylation...

Extracellular signal-regulated kinase (ERK) is a member of the mitogen-activated protein kinase family of signaling molecules. ERK is predominantly found in two forms, ERK1 (p44) and ERK2 (p42), respectively. There are also several atypical forms of …

we decided to compile a comprehensive list of ERK targets and substrates from the accumulating data, which we review in this article. As the RAF-MEK-ERK signaling pathway and the proteomics technolo-gies to uncover the ERK targets are both extensively described elsewhere, this review focuses on discussing

The extracellular signal-regulated kinase (ERK) signaling pathway is a major determinant in the control of diverse cellular processes such as proliferation, survival, differentiation and motility. This pathway is often up-regulated in human tumors and as such represents an attractive target for the …