In this report, we investigated the role of ERK, mitogen-activated protein kinase (MAPK), in Th17 and Treg cell development. We demonstrate that blockade of ERK activation inhibited Th17-cell development while upregulating Treg cells under Th17 polarization conditions.

研究发现以表达细胞因子 IL-17 (Interlukin-17)和转录因子 RORγT 为典型特征的 Th17细胞 促进组织炎症发生，并在宿主抵抗病原体及自身免疫疾病的发病中起到重要作用。 但后续的研究发现Th17细胞在分化和功能上具有两面性。

2013年4月26日 · In this report, we investigated the role of ERK, mitogen-activated protein kinase (MAPK), in Th17 and Treg cell development. We demonstrate that blockade of ERK activation inhibited Th17-cell development while upregulating Treg cells under Th17 polarization conditions.

2009年10月9日 · We found that berberine inhibited Th17 differentiation by activating ERK1/2 and inhibited Th1 differentiation by inhibiting p38 MAPK and JNK activation. Berberine down-regulated the activity of STAT1 and STAT4 through the suppression of p38 MAPK and JNK activation, and it controlled the stability of STAT4 through the ubiquitin-proteasome pathway.

2015年3月16日 · In human memory T H 17 cells, miR-181a regulates responses to cognate antigens through modulation of ERK phosphorylation. By enhancing the signalling cascade from the T-cell receptor, such...

2013年5月1日 · ERK inhibitor-treated Th17 cells function differently from proinflamamtory Th17 cells, in that ERK inhibitor-treated Th17 cells possessed suppressive function in vitro as they inhibited naïve T cell proliferation and IFNγ production at the levels comparable to that of Tregs, and had a decreased potency to induce colitis in vivo.

2010年1月8日 · In this study, we report that pharmacologic inhibition of MEK–ERK signaling enhances the in vitro differentiation of Th17 cells and increases their gene expression of il-17a, il-17f, il-21, il-22, and il-23r. IL-2, which suppresses Th17 differentiation via STAT5 activation, also acts through ERK signaling to inhibit Th17 generation.

2013年7月1日 · In this report, we investigated the role of ERK, mitogen‐activated protein kinase (MAPK), in Th17 and Treg cell development. We demonstrate that blockade of ERK activation inhibited Th17‐cell development while upregulating Treg cells under Th17 polarization conditions.

2010年2月15日 · In this study, we report that pharmacologic inhibition of MEK-ERK signaling enhances the in vitro differentiation of Th17 cells and increases their gene expression of il-17a, il-17f, il-21, il-22, and il-23r. IL-2, which suppresses Th17 differentiation via STAT5 activation, also acts through ERK signaling to inhibit Th17 generation.

2025年3月21日 · Naive CD4 + T cells transfected with Klhl25 targeting siRNAs were cultured under iTreg or Th17 polarization conditions in the presence (or absence) of ERK inhibitor and subsequently analyzed by...