激活的ERK可以磷酸化c-Fos、c-Jun等转录因子，从而在细胞增殖和分化调节中起直接作用。 许多人类的肿瘤组织中都可发现MAPK-ERK信号通路处于异常高表达及高活性状态，促进肿瘤细 …

We discovered that c-Myc is a downstream effector of ERK signaling and that the MEK–ERK–c-Myc central metabolic axis in tumor ECs is essential for tumor progression. As such, disruption …

2024年11月8日 · Results: c-Myc gene knockout in splenic macrophages reduced M2-like polarization and exacerbated liver fibrosis inflammation. c-Myc activated the MAPK signaling …

2020年6月23日 · We begin with a brief overview of the structure, regulation, substrate recognition and subcellular localization of ERK1 and ERK2. We then systematically discuss how ERK …

人类转录因子 Myc 家族是在发现禽骨髓细胞瘤病毒 (v-Myc) 携带的一个癌基因与常在多种肿瘤中过表达的人类基因细胞 Myc（c-Myc）之间存在同源性后确定的。

结果脾巨噬细胞中的 c-Myc 基因敲除减少了 M2 样极化并加剧了肝纤维化炎症。 c-Myc 激活 MAPK 信号通路，并通过 MEK-ERK-c-Myc 轴上调 PH 脾功能亢进中 IL-4 和 M2 样相关基因的 …

1 天前 · Mechanistically, we demonstrate that DYRK1A is regulated by the KMT2A fusion protein and affects cell proliferation by regulating MYC expression and ERK phosphorylation.

MEK/ERK‐mediated oncogenic signals promote EV secretion by lysosomal inactivation. MEK/ERK activation induces c‐MYC expression and suppresses nuclear localization of …

The aberrant accumulation of c-Myc oncoprotein, known to promote PCa onset and progression, may be due to the control of gene transcription and/or MEK/ERK-regulated protein …

2006年8月9日 · We demonstrate that, in all the tumor cell lines used, the MEK/ERK inhibitor U0126 rapidly induces c-Myc de-phosphorylation, which is followed by a marked reduction in …