The serine/threonine-protein kinase/endoribonuclease inositol-requiring enzyme 1 α (IRE1α) is an enzyme that in humans is encoded by the ERN1 gene. [5][6] The protein encoded by this gene …

2024年12月25日 · ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1) is a Protein Coding gene. Diseases associated with ERN1 include Epiphyseal Dysplasia, Multiple, With Early …

ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human triple negative breast cancer. IRE1 deficiency fully restored the learning and memory capacity of AD …

2025年2月9日 · This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein …

2025年2月9日 · Title: Inhibition of signaling protein ERN1 increases the sensitivity of serine synthesis gene expressions to glucose and glutamine deprivations in U87MG glioblastoma …

Here we report that ERN1 (endoplasmic reticulum to nucleus signaling 1), which is upregulated by UPR (unfolded protein response), targets an RNA hairpin loop motif in EGFP mRNA. A silent …

2021年6月1日 · Here, we review the biology of Inositol-requiring enzyme 1β (IRE1β), an ER-resident endonuclease and paralogue of the most evolutionarily conserved ER stress sensor …

2024年11月27日 · In summary, ERN1 is a key sensor in the unfolded protein response, detecting ER stress and activating transcriptional programs that restore balance in the cell. Its highly …

2018年11月27日 · We identify loss of the endoplasmic reticulum (ER) stress sensor IRE1 as synthetic lethal with activated RAS mutants in yeast. In KRAS mutant colorectal cancer cell …

2016年9月14日 · Gene target information for ERN1 - endoplasmic reticulum to nucleus signaling 1 (human). Find diseases associated with this biological target and compounds tested against it …