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2021年7月21日 · Metastatic estrogen receptor α (ERα)-positive breast cancer is presently incurable. Seeking to target these drug-resistant cancers, we report the discovery of a compound, called ErSO, that activates the anticipatory unfolded protein response (a-UPR) and induces rapid and selective necrosis of ERα-po …

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2021年8月12日 · 新发现的小分子化合物erso，具有选择性乳腺癌细胞杀伤作用，且只对雌激素受体（erα）阳性的乳腺癌有效。 erso对初治和内分泌治疗耐药的erα阳性乳腺癌均有效。 erso对原位和转移的erα阳性乳腺癌均有效，包括脑转移的乳腺癌。

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美国伊利诺伊大学香槟分校的研究团队在 Science Translational Medicine 发表最新研究 A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice ，研究指出，此次研究发现的新型分子化合物 ErSO 能与乳腺癌细胞上的雌激素受体结合，增强癌细胞 …

2021年7月26日 · ErSO能够快速破坏大多数肺、骨和肝转移灶，并使脑转移灶急剧缩小. 此次研究中的小分子新药ErSO，不仅能够诱导肿瘤消退，防止癌症复发与转移，还能够抑制肿瘤耐药性的出现。在该项研究中100多只接受ErSO治疗的小鼠体内，研究人员均未观察到ErSO耐药肿瘤。

2021年7月24日 · ErSO由Systems Oncology研发，用于治疗转移性雌激素受体阳性乳腺癌。 在7月22日Science Translational Medicine发表的最新论文中，实验结果显示ErSO能杀死小鼠模型中95%-100%的癌细胞，而且药物还显著减少了肺、骨和脑部的癌转移。

We recently reported ErSO, a compound that induces ERα-dependent cancer cell death through a mechanism distinct from clinically approved ERα drugs, via hyperactivation of the anticipatory unfolded protein response. ErSO has remarkable tumor-eradicative activity in …