The replication cycle of a retrovirus entails the insertion ("integration") of a DNA copy of the viral genome into the nuclear genome of the 展开

The majority of ERVs that occur in vertebrate genomes are ancient, inactivated by mutation, and have reached genetic fixation in … 展开

HERVs comprise a significant part of the human genome, with approximately 98,000 ERV elements and fragments making up 5–8%. According to a study published in 2005, no HERVs capable of replication had been identified; all appeared to be … 展开

Constructing phylogenies
Because most HERVs have no function, are selectively neutral, and are very abundant in primate … 展开

Endogenous retroviruses can play an active role in shaping genomes. Most studies in this area have focused on the genomes of humans and higher primates, but other vertebrates, … 展开

Porcine endogenous retrovirus
For humans, porcine endogenous retroviruses (PERVs) pose a concern when using porcine tissues and organs in xenotransplantation, the … 展开

Whole genome sequencing
Example: A PERV Chinese-born minipig isolate, PERV-A-BM, was sequenced completely and along with different breeds and cell lines in order to … 展开