Aescin or escin is a mixture of saponins with anti-inflammatory, vasoconstrictor and vasoprotective effects found in Aesculus hippocastanum (the horse chestnut). Aescin is the main active component in horse chestnut, and is responsible for most of its medicinal properties.

Escin, the active component of Aesculus hippocastanum, or horse chestnut, is available as orally absorbable dragées and as a transdermal gel. The anti-inflammatory and anti-edematous effects of escin have been studied over many years in pre-clinical models.

Horse chestnut (Aesculus hippocastanum) is a tree. Horse chestnut contains significant amounts of a poison called esculin and can cause death if eaten raw. Horse chestnut also contains a substance...

Escin is a natural mixture of triterpene saponins which mainly consist of several isoforms, in which the α- and β-escin are predominant. β-escin is the major active compound that exerts a therapeutic effect by relieving tissue edema, promoting …

Escin—a plant-derived triterpenoid saponin—is one example of natural products with a broad therapeutic scope. Initially, escin was proven to manifest potent anti-inflammatory and anti-oedematous effects. However, in the last two decades, other novel activities of escin relevant to cancer treatment have been reported.

Oct 20, 2023 · [Formula: see text]-Escin is an oleanane-type pentacyclic triterpenoid saponin extracted from the seeds of Aesculus hippocastanum (AH), which is more widely distributed. [Formula: see text]-Escin sodium has been approved by the American FDA for clinical usage. This paper is intended to summar …

Escin is a compound extracted from horse chestnut seeds, known for its ability to increase venous wall tone and exhibit antiedematous effects. It is poorly absorbed in the digestive tract and is eliminated through the kidney and gallbladder, with maximum activity …

Pentacyclic triterpene saponins, biosynthesized from protoaescigenin and barringtogenol, occurring in the seeds of AESCULUS. It inhibits edema formation and decreases vascular fragility. Conformer generation is disallowed since too many atoms, too flexible, too …

Sep 27, 2019 · This review describes the chemical properties and pharmacology of escin, as well as the pharmacokinetics and clinical uses of escin oral dragée and gel formulations (Reparil ®, Meda Pharma SpA, Milan, Italy – a Mylan Company).

Nov 22, 2024 · Oral horse chestnut seed extract is effective in the short-term treatment of mild to moderate long-term venous insufficiency, but not for post-thrombotic syndrome. Other investigations focus on the role of the major component aescin in male fertility, antiobesity, and anti-inflammatory effects. Aescin gel has been evaluated for use in bruising.