Dr. Abt's research focus has been to address critical gaps in knowledge regarding the functional links between immune cell activation and nucleotide metabolism and to apply this new insight towards the development of immunotherapies for cancer patients.

Scientist with over 10 years of cancer biology research experience. Focused on… My face when I hear NYC’s upcoming budget proposes $58.3 million in cuts to public libraries....

18F-FDG PET Visualizes Systemic STING Agonist-Induced Lymphocyte Activation in Preclinical Models. J Nucl Med. 2023 01; 64 (1):117-123. Le TM, Lee HR, Abt ER, Rashid K, Creech AL, Liang K, Cui J, Cho A, Wei L, Labora A, Chan C, Sanchez E, Kriti K, Karin D, Li L, Wu N, Mona C, Carlucci G, Hugo W, Wu TT, Donahue TR, Czernin J, Radu CG.

Evan ABT | Cited by 807 | of University of California, Los Angeles, CA (UCLA) | Read 37 publications | Contact Evan ABT

My highly interdisciplinary and collaboration-centered research has provided fundamental insight into cancer immuno-metabolism alongside the rationale for clinical trials testing combination immunotherapy regimens.

Identification of actionable immuno-metabolic vulnerabilities of pancreas cancer tumors elicited by mutant-selective KRAS inhibitors. Aim: Therapy. KRAS mutations are the most common drivers of pancreatic ductal adenocarcinoma (PDAC).

2022年8月10日 · Evan Abt is supported by UCLA Tumor Immunology Training Grant T32CA009120. A new study sheds light on the immunoregulatory mechanisms of the metabolic enzyme purine nucleoside phosphorylase (PNP), providing insights for future research and informing a potential therapeutic approach for patients with PNP deficiency.

2022年1月11日 · Abt ER, Rosser EW, Durst MA, Lok V, Poddar S, Le TM, Cho A,Kim W, Wei L, Song J, et al. (2020). Metabolic modifier screen reveals secondary targets of protein kinase inhibitors within nucleotide metabolism.

2021年9月9日 · 第一批作者是来自中国沈阳的外科住院医师Keke Liang和加州大学洛杉矶分校David Geffen医学院的博士后研究员Evan Abt。 作者的完整名单列在期刊文章中。 杂志. 这项研究发表在《美国国家科学院院刊》上。 DOI. 10.1073 / pnas.2105390118. STING-driven interferon signaling triggers metabolic alterations in pancreas cancer cells …

2020年2月2日 · Abt et al. develop and apply a phenotypic screen that leverages this redundancy to identify selective small molecule metabolism modifiers. Multiple compounds developed as protein kinase inhibitors were found to possess secondary targets within nucleotide metabolism.