2024年7月23日 · A panel of chimeric viruses containing sequences from IL52 and CA4231 was used to demonstrate that VP1 is the main determinant of EV-D68 neurovirulence following IM injection of neonatal SW mice. VP1 contains four amino …

There are four identified EV-D68 clades (A, B, C, and D), which have been separated primarily based on sequencing of the VP1 gene encoding a key component of the viral capsid. Clades A and B are prevalent globally across the United States, Europe, and Asia.

2018年11月5日 · Here, we report the structures of three EV-D68 capsid states representing the virus at major phases. We further describe two original monoclonal antibodies (15C5 and 11G1) with distinct...

Enterovirus D68 (EV-D68) is a member of Picornaviridae and is a causative agent of recent outbreaks in the USA of respiratory illness in children. We report here the crystal structures of EV-D68 and its complex with pleconaril, a capsid binding compound that had been developed as an anti-rhinovirus drug.

2024年10月19日 · Here, we demonstrate that peptide P25 from EV-D68 has broad antiviral activity against EV A–D enteroviruses in vitro. P25, derived from the HI loop and β-I sheet of VP1, operates through a conserved hydrophilic motif -R---K-K--K- …

2023年5月17日 · Here, we demonstrate that virus-like particle (VLP) vaccines elicit a protective neutralizing antibody against homologous and heterologous EV-D68 subclades. VLP based on a B1 subclade 2014 outbreak strain elicited comparable B1 EV-D68 neutralizing activity as an inactivated viral particle vaccine in mice.

2 天之前 · Additionally, co-IP experiments validated the interaction between the VP1 proteins of EVD68, CA6, or CA16 and the 1–58 aa peptide of ZYG11B . Fig 7. Fig 7 ZYG11B has a degradation effect on VP1 of EV71, EVD68, CA6, or CA16. (A and B) The regions in the VP1 sequences of EV71, EVD68, CA6, and CA16 that interact with ZYG11B are conserved, and ...

摘要 目的:通过对人肠道病毒D68型(EV-D68)衣壳蛋白VP1理化性质、结构功能和B细胞表位分析,获取候选疫苗肽段用于后期疫苗研制。方法:应用Bioedit软件、Netphos和ExPASy等在线工具分析EV-D68 VP...

2016年4月28日 · Based on sequences of the viral capsid gene VP1, EV-D68 strains are often categorized into 3 distinct genetic groups, clade A to C, in addition to the original Fermon lineage 29, 33. Subsequent...

2023年11月1日 · The capsid protein VP1 is one of the more variable viral proteins with assumed neutralizing epitopes and receptor binding sites, and much phylogenetic analysis relies on VP1 sequences (Tang et al., 2021). In this study, we simultaneously used VP1 and virus full-length sequences to construct a phylogenetic tree.