2024年8月23日 · Exemestane (brand name Aromasin) is an aromatase inhibitor used to lower estrogen levels in women past menopause with early or advanced hormone-sensitive breast cancer. Early breast cancer is cancer that has not spread outside the breast. Advanced breast cancer is cancer that has spread to other parts of the body.

2024年8月19日 · Exemestane belongs to a class of medicines called aromatase inhibitors. It works by blocking an enzyme called aromatase that helps produce estrogen in the body. By lowering the amount of...

Exemestane is an irreversible, steroidal aromatase inactivator of type I, structurally related to the natural substrate 4-androstenedione. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation, an effect also known as " suicide ...

Exemestane is used to treat early and advanced breast cancer in women who have already stopped menstruating (postmenopausal). It is usually used in women who have already received a cancer medication called tamoxifen.

依西美坦，化学名称为6-亚甲基雄甾-1,4-二烯-3,17-二酮，是一种有机化合物，化学式为C20H24O2，为白色至淡黄色结晶性粉末，溶于甲醇，不溶于水，是一种抗肿瘤药，临床上适用于以他莫昔芬治疗后病情进展的绝经后晚期乳腺癌患者。 化学式：C20H24O2. 分子量：296.403. CAS号：107868-30-4. 密度：1.13 g/cm 3. 熔点：155.1°C. 沸点：453.7ºC. 闪点：169ºC. 折射率：1.572. 外观：白色至淡黄色结晶性粉末. 溶解性：溶于甲醇，不溶于水 [1] 摩尔折射 …

依西美坦（INN: exemestane ，商品名Aromasin，台灣譯名諾曼癌素）是治療乳癌的抗雌激素藥物，屬於芳香化酶抑制劑。 某些乳癌細胞具有雌激素 受体 （ER），受 雌激素 刺激而生長，被稱為ER陽性（或稱雌激素反應性、激素反應性或激素受體陽性乳癌）。

What Is Exemestane and How Does It Work? Exemestane is an antineoplastic (anticancer) agent used to treat breast cancer in postmenopausal women. Exemestane is often given to women whose cancer has progressed even after taking tamoxifen (Nolvadex, Soltamox) for 2 to 3 years.

Exemestane is used to treat early breast cancer in women who have experienced menopause ('change of life'; end of monthly menstrual periods) and who have already been treated with a medication called tamoxifen (Nolvadex) for 2 to 3 years.

Exemestane is indicated for the adjuvant treatment of postmenopausal women with estrogen-receptor positive or unknown early breast cancer to reduce the risk of recurrence (distant and loco-regional) and contralateral breast cancer.

Exemestane (FCE 24304) 是一种选择性，不可逆和具有口服活性的甾体芳香酶 (aromatase) 抑制剂，对人胎盘和大鼠卵巢芳香酶的 IC50 分别为 30 nM 和 40 nM。 Exemestane 可用于激素依赖性乳腺癌研究。