2019年9月30日 · ‘T cell exhaustion’ is a broad term that has been used to describe the response of T cells to chronic antigen stimulation, first in the setting of chronic viral infection but more recently in...

2024年11月8日 · CD8 + T cells are critical mediators of antitumor immunity but differentiate into a dysfunctional state, known as T cell exhaustion, after persistent T cell receptor stimulation in the...

2021年7月2日 · 在持续的抗原暴露下（如肿瘤和慢性感染），T细胞最终无法向免疫记忆表型分化，处于功能耗竭状态，被称之为T细胞耗竭（T cell Exhaustion）。 T细胞耗竭四阶段

2019年6月18日 · 急性感染中，CD8+初始T细胞在接受抗原刺激之后，可分化为CD8+效应T细胞 （effector CD8+ T cells, TEFF） 。 如果抗原被清除，一部分的TEFF会持续存在，形成长寿的可以自我更新的记忆T细胞 （memory CD8+ T cells, TMEM ） ，以对再次感染产生快速的免疫反应。

Here, we consider how exhausted T cells can be defined based on transcription factor activity, expression of inhibitory receptors, effector functions, metabolic status and epigenetic status. We also discuss the new ex vivo and in vitro approaches for generating exhausted T cells and how these definitions are being used to identify these cells.

T-cell exhaustion is characterized by the stepwise and progressive loss of T-cell functions and can culminate in the physical deletion of the responding cells. Exhaustion is well-defined during chronic lymphocytic choriomeningitis virus infection ...

2015年7月24日 · T cells exposed to persistent antigen and/or inflammatory signals in chronic infection or cancer can become 'exhausted', a state characterized by a hierarchical loss of effector functions and...

Exhausted T cells lose robust effector functions, express multiple inhibitory receptors and are defined by an altered transcriptional programme. T cell exhaustion is often associated with inefficient control of persisting infections and tumours, but revitalization of exhausted T cells can reinvigorate immunity.

T cell exhaustion is a state of T cell dysfunction that arises during many chronic infections and cancer. It is defined by poor effector function, sustained expression of inhibitory receptors and a transcriptional state distinct from that of functional effector or memory T cells.

What is T Cell Exhaustion? A phenomenon known as “T cell exhaustion” has stymied some efforts to develop powerful immune-based therapies. Through decades of discovery, Penn Medicine researchers are learning why and what to do about it.