外显子 （expressed region），是真核生物基因的一部分，它在剪接后仍会被保存下来，并可在蛋白质生物合成过程中被表达为蛋白质。 外显子是最后出现在成熟RNA中的基因序列，又称表 …

9 小时之前 · The product size of LDLR gene exon 4 was 501bp (Fig. 1). By using Sanger DNA sequencing, different variants in LDLR gene exon 4 were identified in 8 of female patients with …

An exon – EXpressed regiON - is any part of a gene that will form a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing. The term exon refers …

断裂基因/中断基因 是指在DNA序列中，一系列可被表达成RNA或蛋白质的DNA片段（也就是外显子exon）被一系列不能转录成RNA或翻译成蛋白质的DNA片段（也就是intron）给分割开来。

Mutations in coding exon 4 of KRAS were found to occur commonly and to predict for a more favorable clinical outcome in patients with colorectal cancer. Exon 4 KRAS mutations, all of …

2015年7月1日 · Our findings that a human podocyte cell line expresses exon 4-positive and -negative APOL1 transcripts suggest that these variants may play a differential role in podocyte …

2010年7月15日 · Models harboring exon 4 KRAS mutations exhibited mitogen-activated protein/extracellular signal-regulated kinase kinase dependence and resistance to EGFR …

2024年2月14日 · KRAS, the most frequently mutated oncogene in human cancer, produces two isoforms, KRAS4a and KRAS4b, through alternative splicing. These isoforms differ in exon 4, …

Exon-4 mutations at codon 146 affect an evolutionarily conserved region which is predicted to interact with the guanine base of GDP. These lesions do not impair intrinsic KRAS GTPase …

2021年7月3日 · We aimed to assess the prognostic value of KRAS exons 3 and 4 mutations to determine the necessity for their testing. Methods: KRAS mutations in exon 2/3/4 were …