6. UTR （Untranslated Regions）即非翻译区，是信使RNA（mRNA）分子两端的非编码片段。 5'-UTR从mRNA起点的甲基化鸟嘌呤核苷酸帽延伸至AUG起始密码子，3'-UTR从编码区末端的 …

断裂基因/中断基因 是指在DNA序列中，一系列可被表达成RNA或蛋白质的DNA片段（也就是外显子exon）被一系列不能转录成RNA或翻译成蛋白质的DNA片段（也就是intron）给分割开来。

TP53 truncating mutations are common in human tumors and are thought to give rise to p53-null alleles. Here, we show that TP53 exon-6 truncating mutations occur at higher than expected …

• promoter 自然不属于 intron 和 Exon 的任何一个，属于 noncodingsequence 。 • noncoding RNA 是现在研究的热点之一。 我们常见的 MiRNA,SiRNA ,antisense RNA tech, 这些都是属于 …

Exon- 6/exon-7 truncating mutations are indicated in purple. Recent studies from our laboratory have demonstrated that several TP53 truncating mutations occur at the exon-6/exon- 7 …

2020年11月2日 · Here, we show that evolutionary conservation of the exonic PPT correlates well with the degree of AS of exon 6 in two nonhuman primate species and that U2AF2 binding to …

2009年7月8日 · We show that this single, evolutionary conserved exon defines an autonomous structural unit that, despite the minimal structural context, closely matches the structure of the …

Alternative splicing of Runx1 involving exon 6 affects the pool size of hematopoietic stem cells. RUNX1 is an important transcription factor for hematopoiesis. There are multiple alternatively …

2004年5月20日 · Increased levels of exons v6, v9 and v10 are associated with poor prognosis in non-Hodgkin's lymphoma and myeloma, and exon v6 with poor prognosis in acute myeloid …

2014年6月12日 · Together, our results show that Runx1 isoforms involving exon 6 support high self-renewal capacity in vitro, and their loss results in reduction of the HSC pool in vivo, which …