John Frederick Joseph Cade AO [1][2][3] (18 January 1912 – 16 November 1980) was an Australian psychiatrist who in 1948 discovered the effects of lithium carbonate as a mood stabilizer in the treatment of bipolar disorder, then known as manic depression.

1949 年 9 月，凯德将自己开创性的治疗方法发表于《澳大利亚医学杂志》（J. F. J. Cade Med. J. Aus. 2, 349 – 351; 1949）上，他报告了“锂盐治疗 躁狂症 ”，锂对所有 10 个病人起到快速而剧烈的疗效。其中的大多数病人在医院里来来去去，现在有 5 人病情已经稳定 ...

Med J Aust. 1949 Sep 3;2(10):349-52. doi: 10.1080/j.1440-1614.1999.06241.x. Author J F J CADE. PMID: 18142718 DOI: 10.1080/j.1440-1614.1999.06241.x No abstract available. MeSH terms Humans Lithium / therapy* Mental Disorders / therapy* Psychotic Disorders* ...

2006年5月18日 · He is recognized as revolutionizing the treatment of manic depression (bipolar disorder) by introducing the use of lithium. He was aided in this research by Shirley Andrews. After graduating with a medical degree from the University of Melbourne, Cade worked first at St Vincent's Hospital and then at The Royal Children's Hospital.

John F. J. Cade M.D. Senior Medical Officer. Victorian, Department of Mental Hygiene. Search for more papers by this author

John Frederick Joseph Cade (1912-1980), medical scientist, was born on 18 January 1912 at Horsham, Victoria, son of David Duncan Cade, medical practitioner, and his wife Ellen, née Edwards, both Victorian born. David commanded the 3rd Field Ambulance, Australian Imperial Force, during World War I and was awarded the Distinguished Service Order.

2019年8月26日 · Some 70 years ago, John Cade, an Australian psychiatrist, discovered a medication for bipolar disorder that helped many patients to regain stability swiftly. Lithium is now the standard treatment...

John Frederick Joseph Cade was born on 18 January 1912 at Horsham, a small country town in Victoria, Australia. Like his father before him, John Cade entered the medical profession, obtaining his MB, BS (Melbourne) in 1934.

2012年2月1日 · When Cade, a heroic prisoner of war doctor from 1942 to 1945, left Changi Prison, he was bursting with ideas about advancing knowledge of manic-depressive illness. Pursuing a toxic metabolite hypothesis, he first injected urine from manic patients into guinea pigs and, to counter the poor solubility of uric acid, added lithium urate.

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