Fatty acid-binding protein 2 (FABP2), also known as Intestinal-type fatty acid-binding protein (I-FABP), is a protein that in humans is encoded by the FABP2 gene. [5] The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members.

2024年12月25日 · FABP2 (Fatty Acid Binding Protein 2) is a Protein Coding gene. Diseases associated with FABP2 include Maturity-Onset Diabetes Of The Young and Perinatal Necrotizing Enterocolitis. Among its related pathways are Triglyceride metabolism and …

该基因编码的蛋白质是一种细胞内脂肪酸结合蛋白，参与长链脂肪酸的摄取、细胞内代谢和转运。 编码的蛋白质还参与细胞生长和增殖的调节。 这种蛋白质以高亲和力结合饱和长链脂肪酸，可作为维持能量稳态的脂质传感器。 [RefSeq 提供，2017 年 8 月] The protein encoded by this gene is an intracellular fatty acid-binding protein that participates in the uptake, intracellular metabolism, and transport of long-chain fatty acids.

Intestinal fatty acid binding protein is associated with infarct size and cardiac function in acute heart failure following myocardial infarction. Genetic polymorphisms in FABP2, CYP2E1, and TP53 genes are potentially associated with colorectal cancer susceptibility.

In humans, the gene encoding intestinal fatty acid binding protein (I-FABP, also known as FABP2) is located in the q28-q31 region of chromosome 4. FABP2 mRNA encodes a 132-residue protein with an Mr. of 15,124 [37], but the size of the FABP2 protein is 14- to 15-kDa.

fabp2 可以将脂质从肠腔运输到肠细胞并结合多余的脂肪酸以维持上皮细胞中稳定的脂肪酸库。作为脂质伴侣，fabp2还可以携带亲脂性药物以促进靶向转运。当肠上皮的完整性被破坏时，fabp2 被释放到循环中。因此，它可以潜在地用作临床生物标志物。

2022年7月1日 · Intestinal fatty acid binding protein, also termed FABP2 or I-FABP, is specifically expressed in the small intestine. FABP2 can traffic lipids from the intestinal lumen to enterocytes and bind superfluous fatty acids to maintain a steady pool of fatty acids in the epithelium.

2025年2月8日 · Title: Fatty acid binding protein 1 (FABP1) and fatty acid binding protein 2 (FABP2) as a link between diabetic nephropathy and subclinical atherosclerosis in children and adolescents with type 1 diabetes.

2015年8月11日 · In particular, genetic deficiency and small molecule-mediated inhibition of FABP4 (also known as aP2) and FABP5 can potently improve glucose homeostasis and reduce atherosclerosis in mouse models.

2008年6月15日 · Recently, we have demonstrated that the human FABP2 is regulated by the hepatocyte nuclear factor HNF-4α (Klapper et al., 2007a), an endodermal transcription factor that binds fatty acids as ligands. As well as HNF-4α, HNF-1α is also a key regulator of gene expression in pancreatic beta-cells, intestine, kidney, and liver.