2024年12月25日 · FABP7 (Fatty Acid Binding Protein 7) is a Protein Coding gene. Diseases associated with FABP7 include Autism Spectrum Disorder and High Grade Glioma . Among its related pathways are Triglyceride metabolism and Signaling by NOTCH3 .

Fatty acid binding protein 7, brain (FABP7; also brain lipid binding protein, BLBP), is a human gene. [5] The protein encoded by this gene is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands.

脂肪酸结合蛋白7 (FABP7)是一种小分子胞浆蛋白，作为细胞内脂肪酸伴侣与DHA等配体特异性结合并广泛参与机体的生理病理过程。 在脑发育过程中，FABP7在神经干细胞、星型胶质细胞和少突胶质前体细胞中大量表达，在调控中枢神经系统疾病病理过程中发挥重要作用。 本文现围绕FABP7的结构、功能、表达及其在中枢神经系统疾病中的相关研究进展综述如下。 引用本文: 何微微, 彭婷婷, 苟晨, 等. 脂肪酸结合蛋白7在中枢神经系统中的研究进展 [J] . 中华神经医学杂志, …

2022年4月14日 · 哺乳动物的基因组编码至少11种不同的fabps，其中表达在中枢神经系统细胞中的主要有fabp7、fabp5和fabp3[4]。 FABP7又称为脑型脂肪酸结合蛋白B-FABP、脑脂结合蛋白BLBP，是该家族重要成员之一...

2023年12月6日 · Fatty acid-binding protein 7 (FABP7) is vital for uptake and trafficking of fatty acids in the nervous system. To investigate the involvement of FABP7 in...

2024年5月1日 · Fatty acid binding protein 7 (FABP7) is a regulator of cell metabolism and growth that is overexpressed in cancers. FABP7 overexpression in tumours correlates with patient prognosis across many (but not all) cancers.

Nuclear FABP7 regulates cell proliferation of wild-type IDH1 glioma through caveolae formation. Plasma fatty acid-binding protein 7 concentration correlates with depression/anxiety, cognition, and positive symptom in patients with schizophrenia. FABP7 Facilitates Uptake of Docosahexaenoic Acid in Glioblastoma Neural Stem-like Cells.

2023年9月9日 · Fatty acid binding protein 7 (FABP7) belongs to a family of conserved proteins that regulate lipid metabolism, energy homeostasis, and inflammation. FABP7 expression is largely restricted to astrocytes and radial glia-like cells in the adult central nervous system.

2021年5月2日 · This study demonstrates that FABP7 triggers α-synuclein oligomerization through oxidative stress, while FABP7 ligand 6 can inhibit FABP7-induced Syn oligomerization and aggregation, thereby...

Biased expression in brain (RPKM 8.9) and skin (RPKM 0.4). 该基因编码一种小的、高度保守的细胞质蛋白，可结合长链脂肪酸和其他疏水配体。 编码的蛋白质对于在发育中的大脑中建立放射状神经胶质纤维很重要。 选择性剪接和启动子的使用导致编码不同异构体的多个转录变体。 该基因的假基因存在于多条染色体上。 [RefSeq 提供，2016 年 1 月] The gene encodes a small, highly conserved cytoplasmic protein that bind long-chain fatty acids and Other hydrophobic ligands.