2024年12月25日 · FADS1 (Fatty Acid Desaturase 1) is a Protein Coding gene. Diseases associated with FADS1 include Lipid Metabolism Disorder and Vitelliform Macular Dystrophy. Among its related pathways are docosahexaenoate biosynthesis III …

Desaturase enzymes (such as those encoded by FADS1) regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5 -like domain and a C-terminal multiple membrane-spanning desaturase portion ...

该基因编码的蛋白质是脂肪酸去饱和酶 (FADS) 基因家族的成员。 去饱和酶通过在脂肪酰基链的定义碳之间引入双键来调节脂肪酸的不饱和度。 FADS 家族成员被认为是由 N 端细胞色素 b5 样结构域和 C 端多跨膜去饱和酶部分组成的融合产物，两者都具有保守的组氨酸基序特征。 该基因在 11q12-q13.1 与家族成员 FADS1 和 FADS2 聚类；该簇被认为是基于其相似的外显子/内含子组织从基因复制进化而来的。 [RefSeq 提供，2008 年 7 月] The protein encoded by this gene is a …

fads1（脂肪酸去饱和酶1）作为pufa代谢的关键限速酶，可以将dgla（二高-γ-亚麻酸）催化成aa（花生四烯酸）。既往研究发现，fads1在许多癌症中的表达失调，而敲低fads1不仅可以抑制肿瘤的生长和迁移，而且还可以增强化疗药物的细胞毒性。

2022年8月15日 · Fatty Acid Desaturase-1 (FADS1) or delta 5 desaturase (D5D) is a rate-limiting enzyme involved in the biosynthesis of long-chain polyunsaturated fatty acids (LC-PUFAs), i.e., arachidonic acid (ARA) and eicosapentaenoic (EPA). These LC-PUFAs and their metabolites play essential and broad roles in can …

2025年2月8日 · Title: FADS1-arachidonic acid axis enhances arachidonic acid metabolism by altering intestinal microecology in colorectal cancer. Placental expression of Fatty Acid Desaturases 1, 2 and 3 in selected pregnancy pathologies.

铁死亡（Ferroptosis）是一种调节性细胞死亡形式，其特征是依赖铁离子催化，当细胞内还原系统失活后细胞膜或细胞器膜上含不饱和脂肪酸长链的磷脂分子被过氧化破坏，造成细胞膜破裂，于2012年命名为铁死亡。 这种不同于凋亡、坏死、自噬的新型细胞死亡方式，几乎以一己之力摧枯拉朽般地掀起研究狂潮，至今热度不减，已被证明在多种疾病中发挥重要作用，包括癌症、神经退行性疾病和缺血性器官损伤，越来越多的证据表明其在肿瘤抑制和免疫方面具有潜在的生理功 …

The FADS1 gene codes for the fatty acid delta-5 desaturase, a key enzyme in the metabolism of long-chain polyunsaturated omega-3 and omega-6 fatty acids. From: Current Opinion in Biotechnology , 2013

FADS genetic and metabolomic analyses identify the 5 desaturase (FADS1) step as a critical control point in the formation of biologically important lipids. Genetic variants in FADS1 and ELOVL2 increase level of arachidonic acid and the risk of …

Fatty Acid Desaturase (FADS) genes and their variants have been associated with multiple metabolic phenotypes including liver enzymes and hepatic fat accumulation but the detailed mechanism remains unclear. We aimed to delineate the role of FADSs in modulating lipid composition in human liver.