Simplified monomeric VHH-Fc antibodies provide new ... - PubMed
Simplified monomeric monoclonal antibodies consisting of a single-domain VHH, derived from camelid heavy-chain only antibodies, fused with the Fc domain of either IgG (VHH-IgG) or IgA …
First-in-class trispecific VHH-Fc based antibody with potent ...
2022年3月9日 · Here, we evaluated in vivo efficacy and safety of the lead trispecific VHH-Fc, ABS-VIR-001. Importantly, our data showed that ABS-VIR-001 treatment prevented SARS …
Simplified monomeric VHH-Fc antibodies provide new opportunities for ...
2020年2月1日 · Simplified monomeric monoclonal antibodies consisting of a single-domain VHH, derived from camelid heavy-chain only antibodies, fused with the Fc domain of either IgG …
Development and characterization of a camelid derived antibody ...
2022年7月16日 · PCSK9 is an effective target for lowering LDL-c. Previously, a camelid-human chimeric heavy chain antibody VHH-B11-Fc targeting human PCSK9 was designed. It had a …
Camelid VHHs Fused to Human Fc Fragments Provide Long Term …
We demonstrated that modification of neutralizing VHHs with a human immunoglobulin G (IgG)1 Fc (fragment crystallizable) fragment (fusionbody, VHH-Fc) significantly increased the …
Fusion of an Fc chain to a VHH boosts the accumulation levels in ...
2013年8月6日 · Fusion of a ‘fragment crystallizable’ chain (Fc chain) of an antibody to the VHH domain results in a VHH-Fc fusion protein, and due to the Fc auto-oligomerization based on …
Fusion of an Fc chain to a VHH boosts the accumulation levels in ...
Nanobodies® (VHHs) provide powerful tools in therapeutic and biotechnological applications. Nevertheless, for some applications, bivalent antibodies perform much better, and for this, an …
Fusion of hIgG1-Fc to 111In-anti-amyloid single domain ... - PubMed
The fusion protein showed homodimerization - necessary for successful Fc neonatal receptor recycling. Compared to VHH-pa2H, the Fc tailed protein retained high affinity for amyloid beta …
A VHH-Fc Fusion Targeted to the Chloroplast Thylakoid Lumen …
2021年5月28日 · Chimeric fusion proteins comprising a single domain antibody (V H H) fused to a crystallizable fragment (Fc) of an immunoglobulin are modular glycoproteins that are becoming …
VHH single-domain platform enabling discovery and …
2024年5月3日 · A heavy chain-only tetravalent VHH-Fc-VHH bispecific platform derived from humanized synthetic libraries held a myriad of unique advantages: (i) synthetic preconstructed …