2024年10月10日 · Focal cortical dysplasias (FCD) represent a heterogeneous group of disorders of cortical formation, which may demonstrate both architectural and proliferative features. They are one of the most common causes of epilepsy and can be associated with hippocampal sclerosis and cortical glioneuronal neoplasms.

What Is Focal Cortical Dysplasia? Focal Cortical Dysplasia (FCD) is a term used to describe a focal area of abnormal brain cell (“neuron”) organization and development. Brain cells, or “neurons” normally form into organized layers of cells to form the brain “cortex” which is the outermost part of the brain.

Focal cortical dysplasia (FCD) occurs when neurons do not form normally during brain development. Neurons are a specific type of brain cell. Healthy neurons work together with:

2025年2月17日 · Focal cortical dysplasia (FCD) is an important cause of intractable epilepsy, with FCD type II (FCD II) being the most common subtype. FCD II is characterized by cortical dyslamination accompanied by dysmorphic neurons (DNs). Identifying the molecular alterations and targetable biomarkers is pivotal for developing therapies.

2024年11月30日 · Spatial Transcriptomics has provided a new paradigm for understanding FCD. We generated a large dataset of transcriptional changes in the human FCD IIb brain tissues by ST technology. Herein, we focused on the transcriptomic changes in cytoarchitectural abnormalities of FCD, including the DNs and BCs regions.

Focal cortical dysplasias (FCDs) are localized regions of malformed cerebral cortex and are very frequently associated with epilepsy in both children and adults. A broad spectrum of histopathology has been included in the diagnosis of FCD. ...

2020年8月10日 · The term ‘focal cortical dysplasia’ (FCD) refers to a spectrum of focal brain malformations characterized by disordered cortical lamination with or without abnormal cell types. In 2011, FCDs were categorized by the International League Against Epilepsy (ILAE) into three subgroups, essentially at pathology level ( Blümcke et al. , 2011 ):

2024年9月2日 · Focal cortical dysplasia type II (FCD-II) is a prominent cortical development malformation associated with drug-resistant epileptic seizures that leads to...

2020年8月6日 · In this paper, we discuss the literature regarding management of FCD with a focus on etiology, pathophysiology, classification, clinical presentation, and imaging modalities. We will also discuss certain variables affecting surgical outcome of patients with FCD.

2023年3月29日 · 局灶性皮质发育不良 (fcd) ii型是一种高度致痫性的发育畸形，是手术治疗耐药性癫痫的常见适应症。 这种病变的特点是皮层结构异常，巨细胞增生和皮层增厚，可能是由于非典型性神经胶质细胞增殖、生长和迁移所致。