2020年5月18日 · Upon inflammation, the centrally distributed FDC network of the primary B cell follicle is reorganized to underpin the GC light zone (LZ) and a yet-unknown reticular cell type …

fdc直接将天然状态的抗原（通常是被补体或抗体捕获的抗原）吸附于表面，而传统dc需要吞噬抗原，并将其消化为肽段呈递在mhc分子表面。 由于B细胞免疫球蛋白识别的是天然状态的抗原， …

生发中心（germinal center, GC）是抗原特异性B细胞激活后大量增殖形成的结构，其主要组成成分是B细胞，还包括滤泡协助性T细胞（follicular helper T, Tfh）、滤泡树突状细胞（follicular …

2019年11月26日 · Follicular dendritic cells (FDCs), a rare and enigmatic stromal cell type in the B cell follicles of secondary lymphoid organs, store and present antigen to B cells. While …

Follicular dendritic cells (FDCs), a rare and enigmatic stromal cell type in the B cell follicles of secondary lymphoid organs, store and present antigen to B cells. While essential for germinal …

2018年12月18日 · Chen et al. identify the H3K36me2 methyltransferase Nsd2 as a critical regulator of germinal center B (GCB) cell-follicular dendritic cell adhesion. Nsd2 directly …

2019年10月4日 · Human GC B cells are expanded by coculture with a human FDC-derived feeder line engineered to express CD40Lg and IL21. This combination of stimuli was selected to …

To study the functional role of follicular dendritic cells (FDC) in germinal center (GC)-B cell differentiation, we have established an in vitro experimental model that mimics GC-reactions in …

滤泡树突状细胞 (FDC),与一般的 树突状细胞 (DC)功能不同,它不表达MHC-II类分子,其细胞表面有丰富的抗体受体,可与抗原-抗体复合物结合,只有表达与抗原高亲和力抗体的B细胞才能与FDC …

2000年6月1日 · To better understand the differentiative processes occurring within murine GCs, we sought to identify subpopulations of GC B cells corresponding to discrete stages of GC B …