For instance, an ideal FDC would be the ARB, azilsartan and the CCB, amlodipine in a pill form that is scored for ease of splitting and in a convenient dosage. However, at least in the United States, it is not available.

When a combination drug product (whether fixed-dose or not) is a "pill" (i.e., a tablet or capsule), then it may also be a kind of "polypill" or combopill. Initially, fixed-dose combination drug products were developed to target a single disease (such as with antiretroviral FDCs used against AIDS).

2023年5月9日 · Fixed‐dose combination (FDC) antihypertensive products improve blood pressure control and adherence among patients with hypertension. It is unknown to what degree commercially available FDC products meet the current hypertension management prescription patterns in the United States.

2020年10月14日 · Fixed-dose combination (FDC), also known as “single-pill combination,” antihypertensives deliver two or more antihypertensive classes within one pill and offer a more efficient method of intensifying therapy.

The aim of the following practical review is to help physicians choosing the right single-pill FDC, or the right combination of two FDC pills, for the right patient in the daily clinical practice, based on the individual clinical phenotype and CV risk, to improve both treatment effectiveness and adherence, leading to a better control of major ...

2023年12月21日 · In this study we report the in-trial cost effectiveness of a single FDC pill strategy plus aspirin using individual participants data (IPD) from a meta-analysis of the three largest FDC primary CVD prevention trials.

2019年5月31日 · Trials of FDC pills comprising three half-dose or four quarter-dose BP-lowering drugs have shown substantial efficacy. In this Review, we summarize the current evidence on low-dose BP-lowering...

2018年6月11日 · Our study suggests that FDC formulations are associated with better medication adherence and clinical outcomes. Using FDC rather than multipill therapy represents a simple and potentially low-cost intervention that could substantially reduce the global burden of morbidity and mortality related to hypertension.

2011年11月1日 · In spite of advances in prevention and treatment, the burden of cardiovascular diseases is increasing. A fixed-dose combination (FDC) pill, or “polypill,” composed of evidence-based drugs has been proposed as a means of improving cardiovascular prevention by reducing cost and increasing patient adherence to treatment.

Fixed-dose combination (FDC) therapies are hypothesized to enhance compliance by decreasing the number of required pills. Objective: The objective of the study is to compare adherence of a FDC [Glucovance, a FDC of metformin and glyburide] to a 2-pill regimen.