FDC formulations combine several TB drugs (2, 3 or 4) in the same tablet. FDCs are only available for first-line TB drugs. FDCs improve adherence (decreased pill burden, decreased risk of omission of one or more drugs).

We conducted a qualitative exploration into the palatability and acceptability of a novel fixed-dose combination (FDC) anti-tuberculosis drug. This study was nested in the SHINE (Shorter treatment for minimal TB in children) trial, which compares the safety and efficacy of treating non-severe drug-susceptible tuberculosis (TB) with a 6 vs. 4 ...

RECOMMENDED DOSES OF FIRST-LINE ANTITUBERCULOSIS DRUGS FOR ADULTS. The WHO-recommended formulations of anti-TB drugs and fixed-dose combinations (FDCs) of drugs appear in the WHO Model List of Essential Medicines (available at www.who.int/medicines/publications/essentialmedicines/en).

Fixed-dose combinations (FDCs) of drugs for TB treatment have been advocated internationally to prevent the emergence of drug resistance attributable to inappropriate drug intake. 10, 11 Use of FDCs can reduce the risk of an incorrect dosage, simplify drug procurement, and aid in ensuring adherence without changing the drug dosage.

Fixed-dose combination (FDC) formulations are currently recommended for the treatment of active tuberculosis (TB). We have conducted a systematic review to evaluate the risk of treatment failure or disease relapse, acquired drug resistance, bacterial conversion after 2 months of treatment, adverse e …

FDC are formulations containing two or more essential TB drugs in the same tablet, as opposed to conventional ‘loose’ drugs, containing only one active ingredient in each tablet. Both FDC and loose drugs may be provided in convenient blister packs.

Child-friendly formulations: NTPs are encouraged to prioritize the use of child-friendly fixed dose combination (FDC) formulations for TB treatment in children up to 25 kg body weight, such as: the 3-FDC HRZ 50/75/150 mg with or without the addition of dispersible ethambutol, and the 2-FDC HR 50/75 mg (available from the Stop TB Partnership’s ...