2023年9月3日 · TLE dan TLD termasuk dalam jenis ARV Kombinasi Dosis Tetap (KDT) atau Fixed Dose Combination (FDC), yaitu kombinasi tiga atau dua jenis obat yang dikemas dalam satu pil. Berbeda dengan jenis ARV obat tunggal yang hanya mengandung satu jenis obat. TLE adalah kombinasi tiga obat ARV, yaitu Tenofovir, Lamivudine, dan Efavirenz.

Co-formulated fixed dose combination (FDC) of antiretroviral drugs tenofovir disoproxil fumarate, lamivudine, and reduced dose efavirenz [TDF 300 mg/3TC 300mg/EFV400 mg (TLE-400)] is a single daily tablet recently approved for the treatment of HIV-1 infection.

2018年7月23日 · Introduction: Co-formulated fixed dose combination (FDC) of antiretroviral drugs tenofovir disoproxil fumarate, lamivudine, and reduced dose efavirenz [TDF 300 mg/3TC 300mg/EFV400 mg (TLE-400)] is a single daily tablet recently approved for the treatment of HIV-1 …

In the WHO 2016 Consolidated Guidelines on the use of Antiretroviral Drugs for Treating and Preventing HIV Infection, the combination of TDF + 3TC (or emtricitabine (FTC)) + DTG was introduced as an alternative first-line ART regimen for adults, and TDF or abacavir (ABC) + 3TC (or FTC) + DTG as an alternative first-line for adolescents.

2021年1月1日 · Conclusion: The use of a triple-drug regimen (TLE) declined the risk of transmission of HIV from mother-to-child at negligible level, without drug resistance and with safety and tolerability as...

2020年3月16日 · Background: Currently, dolutegravir (DTG) based fixed dose combinations (FDC) of tenofovir/ lamivudine/dolutegravir (TLD) and Abacavir/lamivudine/dolutegravir (ABC/3TC/DTG) is now recommended by...

to the new, single, fixed-dose combination (FDC) tablet containing tenofovir (TDF), emtricitabine (FTC) and efavirenz (EFV). Summary Transitioning from individual drugs to an FDC tablet needs to be managed carefully, particularly regarding stock management, ordering processes, supply-chain integrity and comprehensive patient counselling.

TLD is a fixed-dose combination (FDC) of tenofovir 300mg /lamivudine 300mg /dolutegravir 50mg (TLD) and is considered a desirable FDC to be used as a first-line regimen in people living with HIV.

2023年11月1日 · Obat ARV FDC TLE merupakan Fixed Dose Combination yang terdiri dari tiga jenis obat namun di jadikan satu tablet. FDC TLE terdiri dari Tenofovir disoproxil Fumarat 300 mg, Lamivudine 300 mg dan Efavirenz 600 mg.

This FDC is a complete HIV regimen in treatment naïve patients and allows for once daily dosing with a single tablet. The safety and efficacy of this triple FDC is supported by previously...