Fibroblast growth factor 2 (FGF-2), also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by the FGF2 gene. [5] [6] It binds to and exerts effects via specific fibroblast growth factor receptor (FGFR) proteins, themselves a family of closely related molecules.

2023年4月18日 · 成纤维细胞生长因子2 (fgf2)，也称为碱性fgf (bfgf)，是fgf家族中最早被认可的成员之一。 作为FGFR1、FGFR2、FGFR3和FGFR4的配体，在细胞存活、分裂、分化和迁移的调节中发挥重要作用。

FGF-2 在肌腱到骨的愈合、软骨修复、骨修复和神经再生中发挥着重要作用。 FGF-2 可以特异性结合酪氨酸激酶受体并激活 FGF/FGFR 信号通路。 随后，FGF-2 通过转导其他经典通路，影响细胞增殖、分化和凋亡以及免疫调节。 例如，FGF-2 调控 JAK-STAT 信号通路来调控软骨代谢。 FGF-2 还能够作为有丝分裂促进剂，加速细胞增殖。 因此， (1) FGF-2 是韧带/肌腱损伤愈合过程的重要生长因子。 体外试验中发现，低剂量 FGF-2 能刺激骨髓间充质干细胞增殖和分化，上 …

成纤维细胞生长因子FGF（Fibroblast Growth Factors，FGFs）最初是以其成纤维细胞的有丝分裂能力命名的。 FGF及其受体在动物界高度保守。 在哺乳动物中，FGF家族包括23种多肽，它们调节多种细胞的迁移、增殖、分化、…

Basic fibroblast growth factor (FGF)-2 has been shown to regulate many cellular functions including cell proliferation, migration, and differentiation, as well as angiogenesis in a variety of tissues, including skin, blood vessel, muscle, adipose, tendon/ligament, cartilage, bone, …

Fibroblast growth factor 2 (FGF2) is a protein produced by human cells that exerts molecular effects through its specific receptors. The main roles of these molecules are represented by cell growth, tissue repair, wound healing, tumor growth and angiogenesis [1]. The interaction between PTX3 and FGF2 results in the genesis of PTX3/FGF2 complex.

2020年9月2日 · Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR) signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by...

碱性成纤维生长因子 （bfgf，也称为fgf-2）是 成纤维细胞因子家族 的重要成员。 它具有对肝素的高亲和力，并能特异性地结合 酪氨酸激酶受体 ，进而激活 FGF/FGFR信号通路 。

2024年12月25日 · FGF2 (Fibroblast Growth Factor 2) is a Protein Coding gene. Diseases associated with FGF2 include Corneal Neovascularization and Long Qt Syndrome. Among its related pathways are Downstream signaling of activated FGFR2 and Apoptotic Pathways in Synovial Fibroblasts.

2020年7月1日 · Title: The optimized priming effect of FGF-1 and FGF-2 enhances preadipocyte lineage commitment in human adipose-derived mesenchymal stem cells. Serum fibroblast growth factor-2 levels complement vital biomarkers for diagnosing heart failure.