成纤维细胞生长因子18（fgf18）属于fgf8亚家族成员，在细胞增殖、细胞分化和细胞迁移的调节中起重要作用，是正常骨化和骨骼发育所需，同时刺激肝脏和肠道增殖。

Fibroblast growth factor 18 (FGF-18) is a protein that is encoded by the FGF18 gene in humans. [5] [6] [7] The protein was first discovered in 1998, when two newly-identified murine genes Fgf17 and Fgf18 were described and confirmed as being closely related by sequence homology to …

2024年12月25日 · FGF18 (Fibroblast Growth Factor 18) is a Protein Coding gene. Diseases associated with FGF18 include Lacrimoauriculodentodigital Syndrome 1 and Thanatophoric Dysplasia, Type I. Among its related pathways are Downstream signaling of activated FGFR2 and Apoptotic Pathways in Synovial Fibroblasts.

FGF18 was discovered in 1998. It is a pleiotropic growth factor that stimulates major signalling pathways involved in cell proliferation and growth, and is involved in the development and homeostasis of many tissues such as bone, lung, and central nervous system.

2023年3月4日 · Fibroblast growth factor-18 (FGF18) has diverse organ development and damage repair roles. However, its role in cardiac homeostasis following hypertrophic...

2025年2月8日 · Title: FGF18, a prominent player in FGF signaling, promotes gastric tumorigenesis through autocrine manner and is negatively regulated by miR-590-5p. High FGF18 expression is associated with angiogenesis in hepatocellular carcinoma.

FGF18 serves an essential role in the growth and migration of non-small cell lung cancer cells by regulating the ERK, p38 signaling pathways and MMP26 protein levels. Data suggest that the combination of FIGO stage, ovarian carcinoma type, and/or fibroblast growth factor 18 (FGF18) score could predict poor prognosis among ovarian carcinoma ...

2017年8月30日 · fgf18存在于多种细胞类型中，其功能也并不仅仅局限于骨骼发育，可刺激众多间质细胞和上皮细胞及组织的增殖，包括肺、肾脏、心脏、睾丸、脾脏、骨骼肌和大脑。

2025年2月8日 · Fibroblast growth factor 18 promotes the growth, migration and invasion of MDA‑MB‑231 cells. Association study of FGF18 with developmental dyslexia in Chinese population. IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading.

作者基于主动脉弓缩窄术(tac)诱导的小鼠心肌肥大模型发现，借助aav载体特异性在心肌细胞过表达fgf18（aav-ctnt-fgf18）可缓解心肌细胞肥大，改善心脏功能，抑制细胞凋亡，并伴随ros生成减少；而敲除fgf18则加剧心肌细胞肥大，恶化心脏功能，促进细胞凋亡，并 ...