FGF21 plays an important role in the prediction, treatment, and improvement of prognosis in CVDs. This cardioprotective effect of FGF21 may be achieved by preventing endothelial dysfunction and lipid accumulating, inhibiting cardiomyocyte apoptosis and regulating the associated oxidative stress, inflammation and autophagy.

2018年2月14日 · These results demonstrate that FGF21 functions physiologically and pharmacologically to prevent type 2 diabetic lipotoxicity-induced cardiomyopathy through activation of both AMPK–AKT2–NRF2 ...

2016年3月8日 · FGF21 decreases plasma triglycerides (TGs) in rodents and humans; however, the underlying mechanism or mechanisms are unclear. In the present study, we examined the role of FGF21 in production and disposal of TG-rich lipoproteins (TRLs) in mice.

2023年2月27日 · 在脂滴代谢过程中，围脂滴蛋白家族（perilipins）和脂肪酸转运蛋白（fatty acid transportation protein， FATP）发挥关键作用，可以影响脂滴、内质网和线粒体等细胞器的功能，进而调节细胞代谢。 已有研究表明，高脂膳食和2型糖尿病中伴随着由脂滴代谢引起的内质网应激和非折叠蛋白反应（unfolded protein response，UPR），而perilipins和FATP在其中起到主导作用。 运动是减肥和治疗2型糖尿病的有效手段之一，不同的运动方式可以激活内质网应激反 …

2023年9月12日 · We recently showed that visceral fat directed FGF21 gene therapy improves metabolic and immune health in insulin resistant BTBR mice. Here, we used a fat directed rAAV-FGF21 vector in...

2016年5月1日 · In a recent issue of the Biochemical Journal, Zhen et al. have identified fibroblast activation protein (FAP) as the endopeptidase responsible for this site-specific cleavage of human FGF21 (hFGF21), and propose that inhibition of FAP may be a therapeutic strategy to increase endogenous levels of active FGF21.

2018年1月18日 · Here, we show that FGF21 improves systemic insulin sensitivity by promoting the healthy expansion of subcutaneous adipose tissue (SAT). Serum FGF21 levels positively correlate with the SAT area...

2019年10月1日 · Tanycytes, the hypothalamic ependymo-glia, are located at a privileged position to integrate multiple peripheral inputs. We observed that tanycytes produce and secrete Fgf21 and are located close to Fgf21-sensitive neurons. Fasting, likely via the increase in circulating fatty acids, regulates this central Fgf21 production.

2020年1月1日 · In addition, activation of intestinal-specific FXR by BA could induce the expression of FGF19, which decreases lipogenesis via a SREBP-1c-dependent mechanism and increases FAO via the inhibition of ACC2. FXR activation also induces the expression of FGF21, which is involved in FAO during fasting.

Theis 基因编码成纤维细胞生长因子 (FGF) 家族的成员。 FGF 家族成员具有广泛的促有丝分裂和细胞存活活性，并参与多种生物过程。 这种蛋白质是一种分泌性内分泌因子，起主要代谢调节剂的作用。 编码的蛋白质刺激脂肪组织中葡萄糖的摄取。 [RefSeq 提供，2016 年 3 月] Theis gene encodes a member of the Fibroblast Growth Factor (FGF) family. FGF Family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes.