Fibroblast growth factor 23 (FGF-23) is a protein and member of the fibroblast growth factor (FGF) family which participates in the regulation of phosphate in plasma and vitamin D metabolism. In humans it is encoded by the FGF23 gene. FGF-23 decreases reabsorption of phosphate in …

Fibroblast growth factor (FGF)23 is a phosphaturic hormone produced by osteocytes and osteoblasts that binds to FGF receptors in the presence of the transmembrane protein αKlotho.

成纤维细胞生长因子23（Fibroblast growth factor,FGF23）是近年来明确的磷调节激素。 主要由骨骼中骨细胞合成分泌，少数由成骨细胞和软骨细胞分泌。 FGF23最初发现于 常染色体显性遗传低磷软骨病 （ADHR），后来在肿瘤导致骨软化病和X伴性低磷软骨病中被进一步研究。

FGF23 is a bone-derived hormone that regulates and is regulated by blood levels of phosphate and active vitamin D. Posttranslational glycosylation by the enzyme GALNT3 and subsequent processing by furin, has been demonstrated to be a regulated process that plays a role in regulating FGF23 levels.

The FGF23 gene provides instructions for making a protein called fibroblast growth factor 23, which is produced in bone cells. This protein is necessary in regulating the phosphate levels within the body (phosphate homeostasis).

2024年12月25日 · FGF23 (Fibroblast Growth Factor 23) is a Protein Coding gene. Diseases associated with FGF23 include Hypophosphatemic Rickets, Autosomal Dominant and Tumoral Calcinosis, Hyperphosphatemic, Familial, 2. Among its related pathways are Downstream signaling of activated FGFR2 and Apoptotic Pathways in Synovial Fibroblasts.

More than 20 years ago Fibroblast Growth Factor 23 (FGF23) was identified for the first time . Although FGF23 was first localized in the brain and expected to play a role in the function of the ventro lateral thalamic nucleus, it soon became clear that FGF23 was a phosphaturic hormone and the causative factor of tumor-induced osteomalacia (TIO ...

该基因编码成纤维细胞生长因子蛋白家族的成员，具有广泛的促有丝分裂和细胞存活活性，并参与多种生物过程。 该基因的产物调节肾脏中的磷酸盐稳态和转运。 全长功能性蛋白质可通过切割成 N 端和 C 端链而失活。 该切割位点的突变会导致常染色体显性低磷血症性佝偻病 (ADHR) 。 该基因的突变也与高磷血症家族性肿瘤性钙质沉着症 (HFTC) 有关。 [RefSeq 提供，2013 年 2 月]

成纤维细胞生长因子23 (FGF23)是一种新型内分泌因子，主要在成骨细胞及骨细胞中表达，许多研究发现其与辅因子Klotho蛋白结合后可作用于肾脏、甲状旁腺等组织，参与骨矿物质代谢。 不仅如此，近年来FGF23在骨骼外的作用也逐渐被发现，如FGF23与甲状腺疾病、糖尿病等。 因此了解FGF23的生物学特征、调节机制以及其与相关疾病的关系，对疾病的诊断、治疗具有重要的临床意义。 本文就FGF23与磷代谢性疾病、甲状旁腺功能亢进症、Groves病、骨质疏松症、糖尿病 …

2023年8月8日 · 成纤维细胞生长因子23（FGF23）属于FGF19亚家族成员，由成骨细胞、骨细胞和骨髓合成，是磷酸盐和钙稳态的重要调节剂，同时与铁稳态、炎症和红细胞生成也有关。 FGF23由251个氨基酸组成，属于内分泌型胞外蛋白，1-24区段为信号肽引导分泌，主功能域为25-251区段，也是野生型FGF23的全长形式，包括一对二硫键、2个糖基化位点以及1个磷酸化位点氨基酸修饰。 FGF2与FGF1同作为FGF1亚家族成员，最大的不同在于N端前导肽的长度。 …