2019年7月22日 · Overexpression of EI24 in KO cells could rescue and significantly increase the co-localization of ER and mitochondria, while transfection of EI24-ΔC mutant had no effect on the integrity of ER–mitochondria associations (Fig. 5d), which further demonstrates that the C-terminal of EI24 is essential for the integrity of MAM. We next examined ...

Etoposide-induced protein 2.4 (EI24), located on the endoplasmic reticulum (ER) membrane, has been proposed to be an essential autophagy protein. Specific ablation of EI24 in neuronal and liver tissues causes deficiency of autophagy flux.

Fibroblast growth factor receptor 1 (FGFR-1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome, and CD 331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family.

2009年5月1日 · Nuclear FGFR1 acts as a developmental gene regulator in cooperation with FGF-2, RSK1, and CREB-binding protein (CBP). FRAP analysis revealed three nuclear FGFR1 populations: i) a fast mobile, ii) a slower mobile population reflecting chromatin-bound FGFR1, and iii) an immobile FGFR1 population associated with the nuclear matrix.

2022年2月3日 · Here, we reveal that ER transmembrane protein EI24 promotes cell adaptation to ER stress by coordinating the IRE1 branch of the unfolded protein response (UPR) and calcium signaling. Under nonstressed conditions, EI24 binds to …

EI24(etoposide-induced gene 24)是一种由依托泊苷以依赖于p53的方式诱导的DNA损伤应答基因,可通过p53介导的凋亡途径抑制细胞生长,在多种恶性肿瘤中通过促进癌细胞凋亡发挥抑癌作用.EI24基因编码的位于内质网膜上的EI24蛋白,是一种重要的自噬蛋白,参与自噬小体的形成 ...

2023年4月23日 · EI24 showed a significant association with prognosis and may represent a new indicator of prognosis in patients with cancer. In most cancers, EI24 is closely associated with tumor immunity and interacts with various immune cells.

5 天之前 · We show that the VZ23 inhibits FGFR1 signaling in the presence of cognate fibroblast growth factor (FGF) ligands and its inhibitory activity is linked to its capacity to form unusual G-quadruplex structure.

2020年12月24日 · The overexpression 1 day after UUO through tail vein injection alleviated the progression of renal interstitial fibrosis (RIF). EI24 inhibited epithelial-mesenchymal transition, excessive deposition of the extracellular matrix, and activation of fibroblasts.

Fibroblast growth factor receptors (FGFRs) are a family of receptor tyrosine kinases expressed on the cell membrane that play crucial roles in both developmental and adult cells. Dysregulation of FGFRs has been implicated in a wide variety of cancers, such as urothelial carcinoma, hepatocellular carcinoma, ovarian cancer and lung adenocarcinoma.