
FGFR1 Gene - GeneCards | FGFR1 Protein | FGFR1 Antibody
2024年12月25日 · FGFR1 (Fibroblast Growth Factor Receptor 1) is a Protein Coding gene. Diseases associated with FGFR1 include Osteoglophonic Dysplasia and Encephalocraniocutaneous Lipomatosis. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.
FGFR:信号通路与靶向药物 - 知乎 - 知乎专栏
成纤维细胞生长因子受体 (FGFR)包括FGFR1, FGFR2, FGFR3, FGFR4及FGFRL1 (缺少胞内激酶结构域),由不同基因编码,但结构功能相似,为单次跨膜蛋白,有胞外区,跨膜区,胞内激酶区域组成。 FGFR会出现多种形式的选择性剪切,如外显子1和3的缺失,C-端截断等。 外显子8和9的选择性剪切会改变胞外配体结合的功能,并表现出组织差异性。 IgI、IgII和IgIII是FGFR胞外区的三个片段,为免疫球蛋白结构域,其中IgIII为胞外配体主结合区域,由外显子Exon7,8,9编码 …
FGF/FGFR signaling in health and disease | Signal Transduction …
2020年9月2日 · Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR) signaling has crucial roles in a multitude of processes during embryonic development...
Ligand bias underlies differential signaling of multiple FGFs via FGFR1
2024年4月3日 · Förster resonance energy transfer experiments reveal a correlation between biased signaling and the conformation of the FGFR1c transmembrane domain dimer. Our findings expand the mechanistic understanding of FGF signaling during development and bring the poorly understood concept of receptor tyrosine kinase ligand bias into the spotlight.
Fibroblast Growth Factor Receptors (FGFRs) and Noncanonical …
This occurs primarily through amplification and over-expression of FGFR1 and FGFR2 resulting in ligand-independent activation. Mutations and translocations of FGFR1-4 are also identified in cancer. Canonical FGF-FGFR signaling is tightly regulated by ligand-receptor combinations as well as direct interactions with the FGFR coreceptors heparan ...
GPER Mediates a Feedforward FGF2/FGFR1 Paracrine Activation …
2019年3月7日 · By quantitative PCR (qPCR), western blot, immunofluorescence analysis, ELISA and ChIP assays, we demonstrated that 17β-estradiol (E2) and the G protein estrogen receptor (GPER) agonist G-1 induce the up-regulation and secretion of FGF2 via GPER together with the EGFR/ERK/c-fos/AP-1 signaling cascade in (ER)-negative primary CAFs.
成纤维细胞生长因子受体 1(Fgfr1)基因 | MCE
该基因的人类直系同源基因与多种疾病有关,包括 Jackson-Weiss 综合征;骨病(多发);唇裂;血液系统癌症(多发性);和低促性腺激素性腺功能减退症(多个)。与人 FGFR1(成纤维细胞生长因子受体 1)同源。 [由基因组资源联盟提供,2022 年 4 月]
【杰论系列】伴随诊断及生物标志物篇:FGFR - 知乎
成纤维细胞生长因子受体 (FGFR) 是高度保守、广泛分布的跨膜酪氨酸激酶受体,包括FGFR1、FGFR2、FGFR3、FGFR4四种受体亚型。 成纤维细胞生长因子(FGF)与FGFR结合时,受体二聚化,从而引起受体激酶结构域的细胞内磷酸化、细胞内信号传导和基因转录的级联反应 [1]。 由FGFR激活的信号转导通路包括RAS–RAF–MAPK,PI3K–AKT, STAT 和PLC途径,它们参与调控多种生物学过程,如器官发育、血管新生、细胞增殖、迁移、抗凋亡等(图1)。
Transactivation of G protein-coupled receptors (GPCRs) and …
FRET has confirmed the formation of 5-hydroxytryptamine receptor 1 A (5-HT1A; GPCR) complexes with FGFR1 supporting physiological evidence for these complexes and their role in neuronal plasticity . BRET studies have also revealed the formation of heteromeric complexes between the β2-AR and IR that could underlie the counter-regulatory effects ...
成纤维细胞生长因子受体 1(FGFR1)基因 | MCE
该基因编码的蛋白质是成纤维细胞生长因子受体 (FGFR) 家族的成员,其中氨基酸序列在成员之间和整个进化过程中高度保守。 FGFR 家族成员的配体亲和力和组织分布各不相同。 全长代表性蛋白质由一个细胞外区域组成,该区域由三个免疫球蛋白样结构域、一个疏水性跨膜片段和一个细胞质酪氨酸激酶结构域组成。 蛋白质的细胞外部分与成纤维细胞生长因子相互作用,启动一系列下游信号,最终影响有丝分裂发生和分化。 这个特殊的家族成员结合酸性和碱性成纤维细胞生长 …
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