These studies provide the first direct evidence for both the involvement of the FGFR1 V561M mutation and PTEN inactivation in the development of resistance in leukemias overexpressing …

There are four identified FGFR receptors, FGFR1, FGFR2, FGFR3, and FGFR4 that bind to a variety of FGFs. Twenty-two different FGFs have also been identified. FGF1 through FGF10 …

2020年10月20日 · Treatment with different tyrosine kinase inhibitors (TKIs) revealed that, in both FGFR1 mutation and Pten deletion-mediated resistance, sustained Akt activation in resistant …

In FGFR-driven leukemia, the activation mutation V561M within the FGFR1 tyrosine kinase domain, coupled with inactivation of PTEN, led to increased PI3K/AKT activity and acquired …

2019年9月3日 · PD-L1, FGFR1, PIK3CA, PTEN, and p16 expression were evaluated by immunohistochemistry (IHC). Expression level was classified as tumor cells (TC) 3 (≥ 50%), …

fgfr1激酶结构域中激活的v561m突变和pten的突变失活导致pi3k / akt活性增加。 PTEN突变细胞中PTEN的异位表达使它们对FGFR抑制剂重新敏感。 用BGJ398与BEZ235 PI3K抑制剂联合治 …

目的：纤维母细胞生长因子受体1(fibroblast growth factor receptor 1,FGFR1)基因扩增是目前肺鳞癌中最具有发展潜力药物分子靶点之一.目前,多个FGFR1抑制剂的临床试验正在进行中, …

2024年5月23日 · CX3CR1 inhibition blocked FGFR1 activation triggered by FGF9 and sensitized PTEN-deficient prostate cancer to the AKT inhibitor capivasertib. This study reveals the role of …

In the present report, two unique mechanisms for resistance were identified in FGFR1-resistant cell lines, one involving an activating mutation in FGFR1 and the second mutational …

Background: Fibroblast Growth Factor 20 (FGF20)-FGF receptor 1 (FGFR1) signaling is essential for cochlear hair cell (HC) and supporting cell (SC) differentiation. In other organ systems, …